Stimuli-responsive piezoelectricity in electrospun polycaprolactone (PCL)/Polyvinylidene fluoride (PVDF) fibrous scaffolds for bone regeneration

被引:24
|
作者
Bagherzadeh, Elham [1 ]
Sherafat, Zahra [1 ]
Zebarjad, Seyed Mojtaba [1 ]
Khodaei, Azin [2 ]
Yavari, Saber Amin [2 ]
机构
[1] Shiraz Univ, Sch Engn, Dept Mat Sci & Engn, Shiraz, Iran
[2] Univ Med Ctr Utrecht, Dept Orthoped, Utrecht, Netherlands
来源
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T | 2023年 / 23卷
关键词
Piezoelectric scaffold; Polymers crystallization; Fibrous composite; Bone regeneration;
D O I
10.1016/j.jmrt.2023.01.007
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Polymeric scaffolds are a determinant part of modern tissue engineering owing to their great diversity, adaptability, and processability. Interestingly, the physical properties of these scaffolds, e.g., porosity, mechanical properties, and biocompatibility, can be tuned to make them smart and stimuli-responsive. In this regard, piezoelectric materials can be applied to stimulate bone regeneration by converting mechanical impulses to electrical signals. In the present research, fibers made of various blend ratios of polyvinylidene fluoride (PVDF)/polycaprolactone (PCL) were fabricated, investigated and optimized to promote bone regeneration. Uniform fibers containing b-phase PVDF were obtained due to the simultaneous stretching and high voltage applied during electrospinning. Furthermore, components interaction, crystallinity, and piezoelectric behavior were estimated through fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and piezometery, respectively. The samples showed improved wettability and controlled biodegradability, and the piezoelectric charge output reached up to 7.5 pC/N in the sample containing 70 wt% PVDF. At the same time, these scaffolds could provide mechanical properties close to the native bone tissue relying on the PVDF component. In vitro as-sessments demonstrated that the composite scaffolds were biocompatible and could support cell attachment and proliferation. Moreover, their piezoelectric behavior promoted stem cell differentiation into osteoblasts. Considering the obtained results, the potential of piezoelectric PVDF/PCL blend fibers for bone scaffolds is indisputable.(c) 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
引用
收藏
页码:379 / 390
页数:12
相关论文
共 47 条
  • [21] Magnesium-containing silk fibroin/polycaprolactone electrospun nanofibrous scaffolds for accelerating bone regeneration
    Xing, Xin
    Cheng, Gu
    Yin, Chengcheng
    Cheng, Xin
    Cheng, Yuet
    Ni, Yifeng
    Zhou, Xue
    Deng, Hongbing
    Li, Zubing
    ARABIAN JOURNAL OF CHEMISTRY, 2020, 13 (05) : 5526 - 5538
  • [22] Melt-electrospun polycaprolactone strontium-substituted bioactive glass scaffolds for bone regeneration
    Ren, Jiongyu
    Blackwood, Keith A.
    Doustgani, Amir
    Poh, Patrina P.
    Steck, Roland
    Stevens, Molly M.
    Woodruff, Maria A.
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2014, 102 (09) : 3140 - 3153
  • [23] Preparation and characterization of an electrospun polycaprolactone (PCL) fibrousmat andmulti-layered PCL scaffolds having a nanosized pattern-surface for tissue regeneration
    Jeon, HoJun
    Kim, GeunHyung
    JOURNAL OF MATERIALS CHEMISTRY B, 2014, 2 (02) : 171 - 180
  • [24] Attapulgite-doped electrospun PCL scaffolds for enhanced bone regeneration in rat cranium defects
    Dai, Ting
    Ma, Jiayi
    Ni, Su
    Liu, Chun
    Wang, Yan
    Wu, Siyu
    Liu, Jun
    Weng, Yiping
    Zhou, Dong
    Jimenez-Franco, Ana
    Zhao, Hongbin
    Zhao, Xiubo
    BIOMATERIALS ADVANCES, 2022, 133
  • [25] Ultra-filtration membranes based on electrospun poly(vinylidene fluoride) (PVDF) fibrous composite membrane scaffolds
    Zhou, Wuyi
    Bahi, Addie
    Li, Yingjie
    Yang, Heejae
    Ko, Frank
    RSC ADVANCES, 2013, 3 (29) : 11614 - 11620
  • [26] Designed hybrid scaffolds consisting of polycaprolactone microstrands and electrospun collagen-nanofibers for bone tissue regeneration
    Lee, Hyeongjin
    Yeo, Myunggu
    Ahn, SeungHyun
    Kang, Dong-Oan
    Jang, Chul Ho
    Lee, Haengnam
    Park, Gil-Moon
    Kim, Geun Hyung
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2011, 97B (02) : 263 - 270
  • [27] Effect of Gelatin Coating and GO Incorporation on the Properties and Degradability of Electrospun PCL Scaffolds for Bone Tissue Regeneration
    Loyo, Carlos
    Cordoba, Alexander
    Palza, Humberto
    Canales, Daniel
    Melo, Francisco
    Vivanco, Juan F.
    Baier, Raul Vallejos
    Millan, Carola
    Corrales, Teresa
    Zapata, Paula A.
    POLYMERS, 2024, 16 (01)
  • [28] Synthesis of magnesium phosphate nanoflakes and its PCL composite electrospun nanofiber scaffolds for bone tissue regeneration
    Perumal, Govindaraj
    Sivakumar, Ponnurengam Malliappan
    Nandkumar, A. Maya
    Doble, Mukesh
    MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 109
  • [29] In vitro evaluation of electrospun polyvinylidene fluoride hybrid nanoparticles as direct piezoelectric membranes for guided bone regeneration
    Chen, Wen-Cheng
    Huang, Bo-Yuan
    Huang, Ssu-Meng
    Liu, Shih-Ming
    Chang, Kai-Chi
    Ko, Chia-Ling
    Lin, Chih-Lung
    BIOMATERIALS ADVANCES, 2023, 144
  • [30] In vitro and in vivo studies of rhBMP2-coated PS/PCL fibrous scaffolds for bone regeneration
    Thi-Hiep Nguyen
    Lee, Byong-Taek
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2013, 101 (03) : 797 - 808