Mechanistic Understanding of D-Glucaric Acid to Support Liver Detoxification Essential to Muscle Health Using a Computational Systems Biology Approach

被引：11

作者：

Ayyadurai, V. A. Shiva ^{[1
]}

Deonikar, Prabhakar ^{[1
]}

Fields, Christine ^{[2
]}

机构：

[1] CytoSolve Inc, CytoSolve Res Div, Syst Biol Grp, Cambridge, MA 02138 USA

[2] Appl Food Sci Inc, 8708 South Congress Suite 290, Austin, TX 78745 USA

来源：

NUTRIENTS | 2023年 / 15卷 / 03期

关键词：

liver toxicity; systems biology; D-glucaric acid; muscle soreness; mathematical modeling; CytoSolve; D-SACCHARIC ACID-1,4-LACTONE; BETA-GLUCURONIDASE ACTIVITY; NF-KAPPA-B; OXIDATIVE STRESS; PROPHYLACTIC ROLE; POTENTIAL USE; IN-VITRO; REPERFUSION; METABOLISM; KINETICS;

D O I：

10.3390/nu15030733

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Liver and muscle health are intimately connected. Nutritional strategies that support liver detoxification are beneficial to muscle recovery. Computational-in silico-molecular systems' biology analysis of supplementation of calcium and potassium glucarate salts and their metabolite D-glucaric acid (GA) reveals their positive effect on mitigation of liver detoxification via four specific molecular pathways: (1) ROS production, (2) deconjugation, (3) apoptosis of hepatocytes, and (4) beta-glucuronidase synthesis. GA improves liver detoxification by downregulating hepatocyte apoptosis, reducing glucuronide deconjugates levels, reducing ROS production, and inhibiting beta-Glucuronidase enzyme that reduces re-absorption of toxins in hepatocytes. Results from this in silico study provide an integrative molecular mechanistic systems explanation for the mitigation of liver toxicity by GA.

引用

页数：13

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