The role of deubiquitinases in cardiac disease

被引：12
作者：
Zhan, Xiaona [1 ]
Yang, Yi [1 ]
Li, Qing [1 ]
He, Fan [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Nephrol, Tongji Hosp, Wuhan 430030, Peoples R China
来源：
EXPERT REVIEWS IN MOLECULAR MEDICINE | 2024年 / 26卷
基金：
中国国家自然科学基金;
关键词：
cardiac disease; cardiac fibrosis; cardiac hypertrophy; deubiquitinases; myocardial ischaemia-reperfusion injury; myocarditis; UBIQUITIN-PROTEASOME SYSTEM; HEART-FAILURE; HYPERTROPHY; ACTIVATION; MECHANISMS; AUTOPHAGY; PATHWAY; INJURY; CARDIOMYOPATHY; DEGRADATION;
D O I：
10.1017/erm.2024.2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin chains attached to substrate proteins, preventing the substrate protein from being degraded by the ubiquitin-proteasome system. Deubiquitinases regulate cellular autophagy, metabolism and oxidative stress by acting on different substrate proteins. Recent studies have revealed that deubiquitinases act as a critical regulator in various cardiac diseases, and control the onset and progression of cardiac disease through a board range of mechanism. This review summarizes the function of different deubiquitinases in cardiac disease, including cardiac hypertrophy, myocardial infarction and diabetes mellitus-related cardiac disease. Besides, this review briefly recapitulates the role of deubiquitinases modulators in cardiac disease, providing the potential therapeutic targets in the future.
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页数：10
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