A case of postoperative pancreatitis in patients with renal cell carcinoma with an inferior vena cava tumor thrombus treated by presurgical lenvatinib plus pembrolizumab

被引:1
作者
Kurokawa, Masahiro [1 ,2 ]
Ikarashi, Daiki [1 ]
Kato, Renpei [1 ]
Kanehira, Mitsugu [1 ]
Fukagai, Takashi [2 ]
Obara, Wataru [1 ]
机构
[1] Iwate Med Univ, Dept Urol, Sch Med, 2-1-1 Idaidori,Yahaba Cho, Morioka, Iwate 0283695, Japan
[2] Showa Univ, Sch Med, Dept Urol, Tokyo, Japan
关键词
Pembrolizumab; Lenvatinib; Renal cell carcinoma; Inferior vena cava thrombus; Pancreatitis;
D O I
10.1007/s13691-024-00657-7
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pancreatic injury is a rare, but noted complication of nephrectomy. We report a case involving a 56-year-old man who presented with cT3bN0M0 left locally advanced renal cell carcinoma with an inferior vena cava thrombus. Nephrectomy with thrombectomy was performed given the remarkable shrinkage of the primary tumor and thrombus following lenvatinib plus pembrolizumab administration. The patient developed postoperative pancreatitis associated with unrecognized minor pancreatic injury, which was treated conservatively. To our knowledge, this has been the first case that underwent nephrectomy for RCC with an IVC thrombus after presurgical lenvatinib plus pembrolizumab and received conservative treatment for postoperative pancreatitis.
引用
收藏
页码:158 / 161
页数:4
相关论文
共 50 条
[21]   Multidisciplinary surgical approach for renal cell carcinoma with inferior vena cava tumor thrombus [J].
Tabbara, Marina M. ;
Gonzalez, Javier ;
Ciancio, Gaetano .
SURGERY TODAY, 2022, 52 (07) :1120-1121
[22]   The Choi response criteria for inferior vena cava tumor thrombus in renal cell carcinoma treated with targeted therapy [J].
Kwon, Taekmin ;
Lee, Jae-Lyun ;
Kim, Jeong Kon ;
You, Dalsan ;
Jeong, In Gab ;
Song, Cheryn ;
Ahn, Hanjong ;
Kim, Choung-Soo ;
Hong, Jun Hyuk .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2014, 140 (10) :1751-1758
[23]   The Choi response criteria for inferior vena cava tumor thrombus in renal cell carcinoma treated with targeted therapy [J].
Taekmin Kwon ;
Jae-Lyun Lee ;
Jeong Kon Kim ;
Dalsan You ;
In Gab Jeong ;
Cheryn Song ;
Hanjong Ahn ;
Choung-Soo Kim ;
Jun Hyuk Hong .
Journal of Cancer Research and Clinical Oncology, 2014, 140 :1751-1758
[24]   Imaging predictors for assessment of inferior vena cava wall invasion in patients with renal cell carcinoma and inferior vena cava tumor thrombus: a retrospective study [J].
Wang BinShuai ;
Li YouZhao ;
Fang YangYi ;
Zhang ShuDong ;
Ma LuLin .
中华医学杂志英文版, 2020, 133 (17) :2078-2083
[25]   Imaging predictors for assessment of inferior vena cava wall invasion in patients with renal cell carcinoma and inferior vena cava tumor thrombus: a retrospective study [J].
Wang, Bin-Shuai ;
Li, You-Zhao ;
Fang, Yang-Yi ;
Zhang, Shu-Dong ;
Ma, Lu-Lin .
CHINESE MEDICAL JOURNAL, 2020, 133 (17) :2078-2083
[26]   Effect of Inferior Vena Cava Tumor Thrombus on Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated with Cytoreductive Nephrectomy [J].
Hoeh, Benedikt ;
Flammia, Rocco Simone ;
Hohenhorst, Lukas ;
Sorce, Gabriele ;
Panunzio, Andrea ;
Tappero, Stefano ;
Tian, Zhe ;
Saad, Fred ;
Gallucci, Michele ;
Briganti, Alberto ;
Terrone, Carlo ;
Shariat, Shahrokh F. ;
Graefen, Markus ;
Tilki, Derya ;
Antonelli, Alessandro ;
Kosiba, Marina ;
Mandel, Philipp ;
Kluth, Luis A. ;
Becker, Andreas ;
Chun, Felix K. H. ;
Karakiewicz, Pierre I. .
EUROPEAN UROLOGY OPEN SCIENCE, 2022, 44 :94-101
[27]   Case Report: Radiotherapy Plus Immunotherapy and Lenvatinib for the Treatment of Recurrent Hepatocellular Carcinoma With a Right Atrium and Inferior Vena Cava Tumor Thrombus [J].
Qian, Yuting ;
Gong, Long ;
Li, Su ;
Mao, Kun ;
Li, Xianming ;
Liao, Guixiang .
FRONTIERS IN ONCOLOGY, 2022, 12
[28]   Hypofractionated radiotherapy for renal cell carcinoma with inferior vena cava tumour thrombus [J].
Beldzinska, Karolina ;
Gadek, Konrad ;
Rutkowski, Jacek .
WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY, 2022, 26 (04) :310-313
[29]   The value of a postoperative nomogram based on the primary tumor score for overall survival of patients with renal cell carcinoma and inferior vena cava tumor thrombus [J].
Zhang, Rongjin ;
Liu, Zhuo ;
Zhang, Min ;
Li, Nan ;
Liu, Chang ;
Zhang, Yongyue ;
Sun, Yang ;
Zhang, Shudong ;
Wang, Shumin .
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2025, 43 (03) :190e21-190e28
[30]   Efficacy of TACE Combined with Lenvatinib Plus Sintilimab for Hepatocellular Carcinoma with Tumor Thrombus in the Inferior Vena Cava and/or Right Atrium [J].
Ning, Shangkun ;
Li, Xinge ;
Ma, Xiangyu ;
Liu, Jibing ;
Chang, Xu .
JOURNAL OF HEPATOCELLULAR CARCINOMA, 2023, 10 :1511-1525