Protein-based nanoparticles for therapeutic nucleic acid delivery

被引：15

作者：

Eweje, Feyisayo ^{[1
,2
,3
,4
]}

Walsh, Michelle L. ^{[1
,2
,3
]}

Ahmad, Kiran ^{[1
]}

Ibrahim, Vanessa ^{[1
]}

Alrefai, Assma ^{[1
]}

Chen, Jiaxuan ^{[1
,4
]}

Chaikof, Elliot L. ^{[1
,4
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Surg, Boston, MA 02215 USA

[2] MIT, Harvard & MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Harvard MIT MD PhD Program, Boston, MA 02115 USA

[4] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

来源：

BIOMATERIALS | 2024年 / 305卷

关键词：

Drug delivery; Gene therapy; Recombinant proteins; Nanoparticles; Polypeptides; LOADED GELATIN NANOPARTICLES; INTERSTITIAL FLUID PRESSURE; TARGETED GENE DELIVERY; SILK FIBROIN; IN-VIVO; EXTRACELLULAR-MATRIX; CATIONIZED GELATIN; DRUG-DELIVERY; MESSENGER-RNA; RECOMBINANT PROTEINS;

D O I：

10.1016/j.biomaterials.2023.122464

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

To realize the full potential of emerging nucleic acid therapies, there is a need for effective delivery agents to transport cargo to cells of interest. Protein materials exhibit several unique properties, including biodegradability, biocompatibility, ease of functionalization via recombinant and chemical modifications, among other features, which establish a promising basis for therapeutic nucleic acid delivery systems. In this review, we highlight progress made in the use of non-viral protein-based nanoparticles for nucleic acid delivery in vitro and in vivo, while elaborating on key physicochemical properties that have enabled the use of these materials for nanoparticle formulation and drug delivery. To conclude, we comment on the prospects and unresolved challenges associated with the translation of protein-based nucleic acid delivery systems for therapeutic applications.

引用

页数：23

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