A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

被引：5

作者：

Sri, Sarmi ^{[1
]}

Greenstein, Adam ^{[2
,3
]}

Granata, Alessandra ^{[4
]}

Collcutt, Alex ^{[1
]}

Jochems, Angela C. C. ^{[5
,6
]}

McColl, Barry W. ^{[6
,7
]}

Castro, Blanca Diaz ^{[7
]}

Webber, Caleb ^{[8
]}

Reyes, Carmen Arteaga ^{[5
]}

Hall, Catherine ^{[9
,10
]}

Lawrence, Catherine B. ^{[3
,11
]}

Hawkes, Cheryl ^{[1
,12
]}

Pegasiou-Davies, Chrysia-Maria

Gibson, Claire ^{[13
]}

Crawford, Colin L. ^{[6
,7
]}

Smith, Colin ^{[5
]}

Vivien, Denis ^{[14
,15
]}

McLean, Fiona H. ^{[16
,17
]}

Wiseman, Frances ^{[18
]}

Brezzo, Gaia ^{[6
,7
]}

Lalli, Giovanna

Pritchard, Harry A. T. ^{[2
,3
]}

Markus, Hugh S. ^{[19
]}

Bravo-Ferrer, Isabel ^{[6
,7
]}

Taylor, Jade ^{[3
]}

Leiper, James ^{[20
]}

Berwick, Jason ^{[21
,22
,23
]}

Gan, Jian ^{[6
,7
]}

Gallacher, John ^{[24
]}

Moss, Jonathan ^{[6
,25
,26
]}

Goense, Jozien ^{[27
,28
,29
,30
,31
,32
]}

McMullan, Letitia ^{[9
,10
]}

Work, Lorraine ^{[33
]}

Evans, Lowri ^{[2
,3
]}

Stringer, Michael S. ^{[5
,6
]}

Ashford, M. L. J. ^{[16
,17
]}

Abulfadl, Mohamed ^{[34
]}

Conlon, Nina ^{[2
,3
]}

Malhotra, Paresh ^{[35
,36
,37
]}

Bath, Philip ^{[38
]}

Canter, Rebecca ^{[39
]}

Brown, Rosalind ^{[6
,7
]}

Ince, Selvi ^{[34
]}

Anderle, Silvia ^{[9
,10
,40
]}

Young, Simon ^{[41
]}

Quick, Sophie ^{[6
,25
]}

Szymkowiak, Stefan ^{[7
,8
]}

Hill, Steve ^{[7
,8
]}

Allan, Stuart ^{[3
,11
]}

Wang, Tao ^{[3
,42
,43
]}

机构：

[1] UK Dementia Res Inst Headquarters, 6th Floor Maple House, London W1T 7NF, England

[2] Univ Manchester, Div Cardiovasc Sci, Manchester M13 9PL, England

[3] Univ Manchester, Manchester Acad Hlth Sci Ctr, Geoffrey Jefferson Brain Res Ctr, Manchester, England

[4] Univ Cambridge, Victor Phillip Dahdaleh Heart & Lung Res Inst, Dept Clin Neurosci, Papworth Rd,Cambridge Biomed Campus, Cambridge CB2 0BB, England

[5] Univ Edinburgh, Ctr Clin Brain Sci, Edinburgh, Scotland

[6] Univ Edinburgh, UK Dementia Res Inst Edinburgh, Edinburgh, Scotland

[7] Univ Edinburgh, Ctr Discovery Brain Sci, Chancellors Bldg, Edinburgh, Scotland

[8] Cardiff Univ, UK Dementia Res Inst Cardiff, Cardiff CF24 4HQ, Wales

[9] Univ Sussex, Sch Psychol, Brighton, East Sussex, England

[10] Univ Sussex, Sussex Neurosci, Brighton, East Sussex, England

[11] Univ Manchester, Div Neurosci, Sch Biol Sci, Fac Biol Med & Hlth, Manchester, England

[12] Univ Lancaster, Biomed & Life Sci, Lancaster, England

[13] Univ Nottingham, Sch Psychol, Nottingham NG7 2UH, England

[14] Normandie Univ, GIP Cyceron, Physiopathol & Imaging Neurol Disorders PhIND, Inst Blood & Brain Caen Normandie BB C,INSERM UMR, Caen, France

[15] Caen Normandie Univ Hosp, Dept Clin Res, Caen, France

[16] Univ Dundee, Ninewells Hosp, Sch Med, Div Syst Med, Dundee DD1 9SY, Scotland

[17] Univ Dundee, Med Sch, Dundee DD1 9SY, Scotland

[18] UCL, UK Dementia Res Inst, London WC1N 3BG, England

[19] Univ Cambridge, Stroke Res Grp, Clin Neurosci, Cambridge CB2 0QQ, England

[20] Univ Glasgow, Inst Cardiovasc & Med Sci, BHF Glasgow Cardiovasc Res Ctr, Glasgow, Scotland

[21] Univ Sheffield, Dept Psychol, Sheffield, England

[22] Univ Sheffield, Neurosci Inst, Sheffield, England

[23] Univ Sheffield, Hlth Lifespan Inst, Sheffield, England

[24] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England

[25] Univ Edinburgh, Inst Regenerat & Repair, Ctr Regenerat Med, Edinburgh, Scotland

[26] Univ Illinois, Neurosci Program, Urbana, IL USA

[27] Univ Glasgow, Coll Med Vet & Life Sci, Sch Cardiovasc & Metab Hlth, Glasgow, Scotland

[28] Univ Bristol, Bristol Med Sch, Dept Clin Neurosci, Dementia Res Grp, Bristol BS10 5NB, England

[29] Imperial Coll London, Dept Brain Sci, London, England

[30] Imperial Coll Healthcare NHS Trust, Dept Neurol, London, England

[31] Univ Nottingham, Stroke Trials Unit, Nottingham, England

[32] Nottingham Univ Hosp NHS Trust, Div Med, Stroke, Nottingham, England

[33] SV Hlth Managers LLP, Dementia Discovery Fund, London, England

[34] Univ Oxford, Dementias Platform UK, Dept Psychiat, Oxford OX3 7JX, England

[35] Univ Manchester, Fac Biol Med & Hlth, Sch Biol Sci, Div Evolut Infect & Genom Sci, Manchester, England

[36] Manchester Univ NHS Fdn Trust, Manchester Ctr Genom Med, Manchester, England

[37] Univ Glasgow, Coll Med Vet & Life Sci, Glasgow, Scotland

[38] Univ Edinburgh, Royal Dick Sch Vet Studies, Midlothian, England

[39] Univ Nottingham, Med Sch, Sch Life Sci, Physiol Pharmacol & Neurosci Div, Nottingham NG7 2UH, England

[40] UCL Queen Sq Inst Neurol, Dept Neuroinflammat, London, England

[41] St Georges Univ London, Mol & Clin Sci Res Inst, London SW17 0RE, England

[42] St Georges Univ Hosp NHS Fdn Trust, Dept Neurol, London, England

[43] Univ Edinburgh, Roslin Inst, Royal Dick Sch Vet Studies, Edinburgh, Scotland

[44] Imperial Coll London, UK Dementia Res Inst, Care Res & Technol Ctr, London, England

[45] Univ Surrey, Guildford, England

[46] Univ Illinois, Dept Psychol, Champaign, IL USA

[47] Univ Illinois, Dept Bioengn, Urbana, IL USA

[48] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL USA

[49] UCL, Dept Neurosci Physiol & Pharmacol, London, England

[50] Univ Glasgow, Sch Psychol & Neurosci, Glasgow, Scotland

来源：

CEREBRAL CIRCULATION-COGNITION AND BEHAVIOR | 2023年 / 5卷

基金：

英国医学研究理事会;

关键词：

Vascular cognitive impairment; Vascular dementia; Small vessel disease; Cerebral vascular disease; Dementia; SMALL VESSEL DISEASE; COGNITIVE IMPAIRMENT; EXPERIMENTAL-MODELS; ISCHEMIC-STROKE; ANIMAL-MODELS; ALZHEIMERS-DISEASE; RODENT MODELS; MECHANISMS; MICE; RAT;

D O I：

10.1016/j.cccb.2023.100189

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Although dementia research has been dominated by Alzheimer's disease (AD), most dementia in older people is now recognised to be due to mixed pathologies, usually combining vascular and AD brain pathology. Vascular cognitive impairment (VCI), which encompasses vascular dementia (VaD) is the second most common type of dementia. Models of VCI have been delayed by limited understanding of the underlying aetiology and pathogenesis. This review by a multidisciplinary, diverse (in terms of sex, geography and career stage), cross-institute team provides a perspective on limitations to current VCI models and recommendations for improving translation and reproducibility. We discuss reproducibility, clinical features of VCI and corresponding assessments in models, human pathology, bioinformatics approaches, and data sharing. We offer recommendations for future research, particularly focusing on small vessel disease as a main underpinning disorder.

引用

页数：12

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