Effects of Redox Homeostasis and Mitochondrial Damage on Alzheimer's Disease

被引：6
作者：
Wu, Yi-Hsuan [1 ]
Hsieh, Hsi-Lung [1 ,2 ,3 ]
机构：
[1] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan 333, Taiwan
[2] Chang Gung Univ Sci & Technol, Grad Inst Hlth Ind Technol, Dept Nursing, Div Basic Med Sci, Taoyuan 333, Taiwan
[3] Chang Gung Mem Hosp, Dept Neurol, Taoyuan 333, Taiwan
来源：
ANTIOXIDANTS | 2023年 / 12卷 / 10期
关键词：
Alzheimer's disease; tau; beta-amyloid; APOE4; redox homeostasis; mitochondrial dysfunctions; INDUCED OXIDATIVE STRESS; AMYLOID-BETA; MOUSE MODEL; VITAMIN-E; NEURODEGENERATIVE DISEASES; A-BETA; NEUROFIBRILLARY TANGLES; TARGETED ANTIOXIDANT; COGNITIVE IMPAIRMENT; SYNAPTIC DYSFUNCTION;
D O I：
10.3390/antiox12101816
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bioenergetic mitochondrial dysfunction is a common feature of several diseases, including Alzheimer's disease (AD), where redox imbalance also plays an important role in terms of disease development. AD is an age-related disease and begins many years before the appearance of neurodegenerative symptoms. Intracellular tau aggregation, extracellular beta-amyloid (A beta) deposition in the brain, and even the APOE4 genotype contribute to the process of AD by impairing redox homeostasis and mitochondrial dysfunction. This review summarizes the evidence for the redox imbalance and mitochondrial dysfunction in AD and demonstrates the current therapeutic strategies related to mitochondrial maintenance.
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页数：18
相关论文
共 151 条
  • [1] Parkin function in Parkinson's disease
    Arkinson, Connor
    Walden, Helen
    [J]. SCIENCE, 2018, 360 (6386) : 267 - 268
  • [2] Reductive stress in young healthy individuals at risk of Alzheimer disease
    Badia, Mari-Carmen
    Giraldo, Esther
    Dasi, Francisco
    Alonso, Dolores
    Lainez, Jose M.
    Lloret, Ana
    Vina, Jose
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2013, 63 : 274 - 279
  • [3] Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model
    Baek, Seung Hyun
    Park, So Jung
    Jeong, Jae In
    Kim, Sung Hyun
    Han, Jihoon
    Kyung, Jae Won
    Baik, Sang-Ha
    Choi, Yuri
    Choi, Bo Youn
    Park, Jin Su
    Bahn, Gahee
    Shin, Ji Hyun
    Jo, Doo Sin
    Lee, Joo-Yong
    Jang, Choon-Gon
    Arumugam, Thiruma V.
    Kim, Jongpil
    Han, Jeung-Whan
    Koh, Jae-Young
    Cho, Dong-Hyung
    Jo, Dong-Gyu
    [J]. JOURNAL OF NEUROSCIENCE, 2017, 37 (20) : 5099 - 5110
  • [4] The Role of Mitochondrial Damage-Associated Molecular Patterns in Chronic Neuroinflammation
    Bajwa, Ekta
    Pointer, Caitlin B.
    Klegeris, Andis
    [J]. MEDIATORS OF INFLAMMATION, 2019, 2019
  • [5] Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives
    Baker, Darren J.
    Petersen, Ronald C.
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (04) : 1208 - 1216
  • [6] Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease
    Ballesteros-Alvarez, Josue
    Nguyen, Wynnie
    Sivapatham, Renuka
    Rane, Anand
    Andersen, Julie K. K.
    [J]. GEROSCIENCE, 2023, 45 (02) : 1095 - 1113
  • [7] HYDROGEN-PEROXIDE MEDIATES AMYLOID-BETA PROTEIN TOXICITY
    BEHL, C
    DAVIS, JB
    LESLEY, R
    SCHUBERT, D
    [J]. CELL, 1994, 77 (06) : 817 - 827
  • [8] Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
    Bezprozvanny, Ilya
    Mattson, Mark P.
    [J]. TRENDS IN NEUROSCIENCES, 2008, 31 (09) : 454 - 463
  • [9] Blass JP, 2000, ANN NY ACAD SCI, V924, P170
  • [10] Mitochondrial Aspects of Synaptic Dysfunction in Alzheimer's Disease
    Cai, Qian
    Tammineni, Prasad
    [J]. JOURNAL OF ALZHEIMERS DISEASE, 2017, 57 (04) : 1087 - 1103
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