The impact of time to surgery on oncological outcomes in stage I-III dMMR colon cancer - A nationwide cohort study

被引：2

作者：

Justesen, Tobias Freyberg ^{[1
]}

Gogenur, Mikail ^{[1
]}

Clausen, Johan Stub Rono ^{[1
]}

Mashkoor, Maliha ^{[1
]}

Rosen, Andreas Weinberger ^{[1
]}

Gogenur, Ismail ^{[1
,2
]}

机构：

[1] Zealand Univ Hosp, Ctr Surg Sci, Lykkebaekvej 1, DK-4600 Koge, Denmark

[2] Univ Copenhagen, Dept Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark

来源：

EJSO | 2023年 / 49卷 / 09期

关键词：

Colon cancer; Deficient mismatch repair system; Treatment interval; Immunotherapy; COLORECTAL-CANCER; TREATMENT DELAYS; SURVIVAL; FLUOROURACIL; DIAGNOSIS; RISK;

D O I：

10.1016/j.ejso.2023.03.223

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Introduction: One of the considerations when investigating neoadjuvant interventions is the prolonging of time from diagnosis to curative surgery (i.e. the treatment interval [TI]). The aim of this study was to investigate the association between the length of TI and overall survival and disease-free survival in patients with deficient mismatch repair (dMMR) colon cancer. Materials and methods: This retrospective propensity score-adjusted study included all patients of >= 18 years of age undergoing elective curative surgery for stage I-III, dMMR colon cancer. Data were extracted from four Danish patient databases. Outcomes were investigated in groups with TIs of <= 14 days versus >14 days. Propensity scores were computed using all demographics, diagnoses and measurements. Matching was done in a 1:1 ratio. Results: A total of 4130 patients were included in the study with a mean age of 73.8 years and a median follow-up time of 43.9 months. After matching, 2794 patients were included in the analysis of overall survival. No significant difference in overall survival was seen between patients with TIs of <= 14 days versus >14 days (hazard ratio [HR], 0.97; 95% confidence interval [CI], 0.81-1.17; p = 0.78). In the analysis of disease-free survival, 1798 patients were included after matching. This showed no significant difference between patients with TIs of <= 14 days versus >14 days (HR, 0.85; 95% CI, 0.69-1.06; p = 0.14). Conclusion: No associations were found between TI and overall survival and disease-free survival in patients with stage I-III, dMMR colon cancer undergoing elective curative surgery.(c) 2023 Elsevier Ltd, BASO - The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

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