BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine

被引：2

作者：

Perera, Dilhan J. ^{[1
,2
]}

Domenech, Pilar ^{[2
,3
]}

Babuadze, George Giorgi ^{[4
,11
]}

Naghibosadat, Maedeh ^{[4
]}

Alvarez, Fernando ^{[2
,5
]}

Koger-Pease, Cal ^{[1
,2
]}

Labrie, Lydia ^{[2
,5
]}

Stuible, Matthew ^{[7
]}

Durocher, Yves ^{[7
]}

Piccirillo, Ciriaco A. ^{[1
,2
,5
]}

Lametti, Andre ^{[6
]}

Fiset, Pierre Olivier ^{[6
]}

Elahi, Seyyed Mehdy ^{[7
]}

Kobinger, Gary P. ^{[8
]}

Gilbert, Renald ^{[7
]}

Olivier, Martin ^{[1
,2
,5
]}

Kozak, Robert ^{[4
,9
]}

Reed, Michael B. ^{[2
,3
]}

Ndao, Momar ^{[1
,2
,5
,10
]}

机构：

[1] McGill Univ, Div Expt Med, Montreal, PQ, Canada

[2] McGill Univ, Res Inst, Hlth Ctr, Infect Dis & Immun Global Hlth Program, Montreal, PQ, Canada

[3] McGill Univ, McGill Int TB Ctr, Montreal, PQ, Canada

[4] Univ Toronto, Sunnybrook Res Inst, Dept Biol Sci, Toronto, ON, Canada

[5] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada

[6] McGill Univ, Dept Pathol, Montreal, PQ, Canada

[7] Natl Res Council Canada, Human Hlth Therapeut Res Ctr, Dept Prod Platforms & Analyt, Montreal, PQ, Canada

[8] Univ Laval, Dept Microbiol Infectiol & Immunol, Fac Medecine, Quebec City, PQ, Canada

[9] Sunnybrook Hlth Sci Ctr, Dept Lab Med & Mol Diagnost, Div Microbiol, Toronto, ON, Canada

[10] McGill Univ Hlth Ctr, Natl Reference Ctr Parasitol, Montreal, PQ, Canada

[11] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX USA

来源：

ISCIENCE | 2023年 / 26卷 / 09期

关键词：

BACILLUS-CALMETTE-GUERIN; TRAINED IMMUNITY; INFECTION; MEMORY; INDUCTION; RESPONSES; COVID-19; EFFICACY; ANTIBODY; CELLS;

D O I：

10.1016/j.isci.2023.107612

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent publications have explored intranasal (i.n.) adenovirus-based (Ad) vaccines as an effective strategy for SARS-CoV-2 in pre-clinical models. However, the effects of prior immunizations and infections have yet to be considered. Here, we investigate the immunomodulatory effects of Mycobacterium bovis BCG pre immunization followed by vaccination with an S-protein-expressing i.n. Ad, termed Ad(Spike). While i.n. Ad(Spike) retains some protective effect after 6 months, a single administration of BCG-Danish prior to Ad(Spike) potentiates its ability to control viral replication of the B.1.351 SARS-CoV-2 variant within the respiratory tract. Though BCG-Danish did not affect Ad(Spike)-generated humoral immunity, it promoted the generation of cytotoxic/Th1 responses over suppressive FoxP3(+) TREG cells in the lungs of infected mice. Thus, this vaccination strategy may prove useful in limiting future pandemics by potentiating the long-term efficacy of mucosal vaccines within the context of the widely distributed BCG vaccine.

引用

页数：22

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