Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease

被引：6

作者：

Bechelli, Clemence ^{[1
]}

Macabrey, Diane ^{[1
]}

Deglise, Sebastien ^{[1
]}

Allagnat, Florent ^{[1
,2
]}

机构：

[1] Lausanne Univ Hosp, Dept Vasc Surg, CH-1005 Lausanne, Switzerland

[2] CHU Vaudois, Dept Sci Biomed, Serv Chirurg Vasc, Bugnon 7A, CH-1005 Lausanne, Switzerland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 12期

关键词：

peripheral artery disease; PAD; intimal hyperplasia; hydrogen sulfide; H2S; atherosclerosis; inflammation; calcification; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL PROGENITOR CELLS; CONVERTING ENZYME-INHIBITOR; CALCIUM SENSING RECEPTOR; VASCULAR CALCIFICATION; NITRIC-OXIDE; MICROVASCULAR DYSFUNCTION; MYOCARDIAL-INFARCTION; PROMOTES ANGIOGENESIS; ENDOGENOUS H2S;

D O I：

10.3390/ijms24129955

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peripheral artery disease (PAD) affects more than 230 million people worldwide. PAD patients suffer from reduced quality of life and are at increased risk of vascular complications and all-cause mortality. Despite its prevalence, impact on quality of life and poor long-term clinical outcomes, PAD remains underdiagnosed and undertreated compared to myocardial infarction and stroke. PAD is due to a combination of macrovascular atherosclerosis and calcification, combined with microvascular rarefaction, leading to chronic peripheral ischemia. Novel therapies are needed to address the increasing incidence of PAD and its difficult long-term pharmacological and surgical management. The cysteine-derived gasotransmitter hydrogen sulfide (H2S) has interesting vasorelaxant, cytoprotective, antioxidant and anti-inflammatory properties. In this review, we describe the current understanding of PAD pathophysiology and the remarkable benefits of H2S against atherosclerosis, inflammation, vascular calcification, and other vasculo-protective effects.

引用

页数：28

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