Quantification of Waning Immunity After Measles Vaccination-Evidence From a Seroprevalence Study

被引：6
作者：
Zibolenova, Jana [1 ]
Hudeckova, Henrieta [1 ]
Chladna, Zuzana [2 ]
Malobicka, Eva [1 ]
Novak, Martin [1 ]
Waczulikova, Iveta [3 ]
Mikas, Jan [4 ]
Mecochova, Adriana [4 ]
机构：
[1] Comenius Univ, Jessenius Fac Med Martin, Dept Publ Hlth, Mala Hora 11149-4B, Martin 03601, Slovakia
[2] Comenius Univ, Fac Math Phys & Informat, Dept Appl Math & Stat, Bratislava, Slovakia
[3] Comenius Univ, Fac Math Phys & Informat, Dept Nucl Phys & Biophys, Bratislava, Slovakia
[4] Publ Hlth Author Slovak Republ, Bratislava, Slovakia
来源：
AMERICAN JOURNAL OF EPIDEMIOLOGY | 2023年 / 192卷 / 08期
关键词：
measles; seroprevalence; vaccination; waning immunity; MUMPS; PERSISTENCE; ANTIBODIES; OUTBREAK;
D O I：
10.1093/aje/kwad065
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
We aimed to quantify rates of waning immunity after measles vaccination from seroprevalence data collected in a study of a population with high vaccination coverage and a fixed vaccination schedule. Data were collected during a national survey (the Immunological Survey) carried out in the Slovak Republic in 2018. The average rate of waning immunity against measles after the first dose of measles, mumps, and rubella (MMR) vaccine (ages 1.5-10 years) was 9.7% per year from the geometric mean titer value of 2,634 mUI/mL. The average waning rate after the second dose of MMR vaccine (ages 10-33 years) was significantly lower: 4.8% per year from the lower geometric mean titer of 1,331 mUI/mL. This decline in antibody levels suggests that vaccine-induced protection may be compromised and results in an increase in the proportion of seronegative/borderline individuals. These outcomes may provide a valuable source for critical assessment of direct and indirect effects of MMR vaccination.
引用
收藏
页码：1379 / 1385
页数：7
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