The biological functions of europium-containing biomaterials: A systematic review

被引：33

作者：

Wu, Likun ^{[1
,2
]}

Yang, Fan ^{[1
,2
]}

Xue, Yijia ^{[1
,2
]}

Gu, Ranli ^{[1
,2
]}

Liu, Hao ^{[1
,2
]}

Xia, Dandan ^{[2
,3
,4
]}

Liu, Yunsong ^{[1
,2
,4
]}

机构：

[1] Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China

[2] Minist Hlth, Natl Ctr Stomatol, Natl Clin Res Ctr Oral Dis, Res Ctr Engn & Technol Computerized Dent,Natl Engn, Beijing 100081, Peoples R China

[3] Peking Univ, Sch & Hosp Stomatol, Dept Dent Mat, Beijing 100081, Peoples R China

[4] Peking Univ, Sch & Hosp Stomatol, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China

来源：

MATERIALS TODAY BIO | 2023年 / 19卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Angiogenesis; Antibacterial; Anti; -tumor; Europium; Nerve regeneration; Osteogenesis; RARE-EARTH-ELEMENTS; IN-VIVO; OSTEOGENIC DIFFERENTIATION; DOPED HYDROXYAPATITE; HYDROXIDE NANORODS; BIOACTIVE GLASSES; BONE REGENERATION; NANOPARTICLES; DRUG; ANGIOGENESIS;

D O I：

10.1016/j.mtbio.2023.100595

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The biological functions of rare-earth elements (REEs) have become a focus of intense research. Recent studies have demonstrated that ion doping or alloying of some REEs can optimize the properties of traditional biomaterials. Europium (Eu), which is an REE with low toxicity and good biocompatibility, has promising applications in biomedicine. This article systematically reviews the osteogenic, angiogenic, neuritogenic, antibacterial, and anti-tumor properties of Eu-containing biomaterials, thereby paving the way for biomedical applications of Eu. Data collection for this review was completed in October 2022, and 30 relevant articles were finally included. Most articles indicated that doping of Eu ions or Eu-compound nanoparticles in biomaterials can improve their osteogenic, angiogenic, neuritogenic, antibacterial, and anti-tumor properties. The angiogenic, antibacterial, and potential neuritogenic effects of Eu(OH)3 nanoparticles have also been demonstrated.

引用

页数：14

共 102 条

[1] Electrospun polycaprolactone (PCL) scaffolds embedded with europium hydroxide nanorods (EHNs) with enhanced vascularization and cell proliferation for tissue engineering applications [J].