Synthesis of Secondary Trifluoromethyl Boronic Esters through Visible Light Induced Decarboxylative Alkylation Reactions

被引：3

作者：

Li, Weipiao ^{[1
,2
]}

Gao, Jiajun ^{[1
,2
]}

Mao, Ting ^{[1
,2
]}

Li, Xuefei ^{[3
]}

Wang, An-Jun ^{[2
]}

Wang, Pan ^{[1
]}

Wang, Hao-Yang ^{[2
,4
]}

He, Chun-Yang ^{[1
,2
]}

机构：

[1] Zunyi Med Univ, Affiliated Hosp Zunyi Med Univ, Dept Nucl Med, Zunyi 563000, Guizhou, Peoples R China

[2] Zunyi Med Univ, Gener Drug Res Ctr Guizhou Prov, Key Lab Biocatalysis & Chiral Drug Synth Guizhou P, Zunyi 563000, Guizhou, Peoples R China

[3] United Imaging Healthcare Grp Co Ltd, Cent Res Inst, Shanghai 201800, Peoples R China

[4] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2023年 / 365卷 / 10期

基金：

中国国家自然科学基金;

关键词：

trifluoromethyl boronic esters; electron donor-acceptor complex; visible light induced; alkylation; QUATERNARY CARBONS; CONSTRUCTION; CF3;

D O I：

10.1002/adsc.202300133

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We demonstrated a practical and general methodology for the synthesis of secondary trifluoromethyl boronic esters through visible light induced decarboxylative alkylation reaction. This reaction was driven by the photochemical activity of electron donor-acceptor (EDA) complex. Except for wide group tolerance, moderate to high yields and simple reaction conditions, the practicality of this protocol was further demonstrated by direct modification of bioactive molecules and further derivations.

引用

页码：1596 / 1601

页数：6

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