Causal associations between major depressive disorder and COVID-19

被引:28
作者
Baranova, Ancha [1 ,2 ]
Zhao, Yi [3 ]
Cao, Hongbao [1 ]
Zhang, Fuquan [3 ,4 ]
机构
[1] George Mason Univ, Sch Syst Biol, Fairfax, VA USA
[2] Res Ctr Med Genet, Moscow, Russia
[3] Nanjing Med Univ, Dept Psychiat, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China
[4] Nanjing Med Univ, Inst Neuropsychiat, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China
关键词
COVID-19; depressive disorder; major; Mendelian randomization analysis; depression; genetics; behavioral;
D O I
10.1136/gpsych-2022-101006
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background We aimed to evaluate whether major depressive disorder (MDD) could aggravate the outcomes of coronavirus disease 2019 (COVID-19) or whether the genetic liability to COVID-19 could trigger MDD. Aims We aimed to assess bidirectional causal associations between MDD and COVID-19. Methods We performed genetic correlation and Mendelian randomisation (MR) analyses to assess potential associations between MDD and three COVID-19 outcomes. Literature-based network analysis was conducted to construct molecular pathways connecting MDD and COVID-19. Results We found that MDD has positive genetic correlations with COVID-19 outcomes (r(g): 0.10-0.15). Our MR analysis indicated that genetic liability to MDD is associated with increased risks of COVID-19 infection (odds ratio (OR)=1.05, 95% confidence interval (CI): 1.00 to 1.10, p=0.039). However, genetic liability to the three COVID-19 outcomes did not confer any causal effects on MDD. Pathway analysis identified a panel of immunity-related genes that may mediate the links between MDD and COVID-19. Conclusions Our study suggests that MDD may increase the susceptibility to COVID-19. Our findings emphasise the need to increase social support and improve mental health intervention networks for people with mood disorders during the pandemic.
引用
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页数:7
相关论文
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Zhang, Fuquan ;
Rao, Shuquan ;
Cao, Hongbao ;
Zhang, Xiangrong ;
Wang, Qiang ;
Xu, Yong ;
Sun, Jing ;
Wang, Chun ;
Chen, Jiu ;
Xu, Xijia ;
Zhang, Ning ;
Tian, Lin ;
Yuan, Jianmin ;
Wang, Guoqiang ;
Cai, Lei ;
Xu, Mingqing ;
Baranova, Ancha .
JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (03)