Imaging the right atrium in pulmonary hypertension: A systematic review and meta-analysis

被引：11

作者：

Richter, Manuel J. ^{[1
,22
]}

Fortuni, Federico ^{[2
,3
]}

Alenezi, Fawaz ^{[4
]}

D'Alto, Michele ^{[5
]}

Badagliacca, Roberto ^{[6
]}

Brunner, Nathan W. ^{[7
]}

Dijk, Arie P. van ^{[8
]}

Douschan, Philipp ^{[1
,9
]}

Gall, Henning ^{[1
]}

Ghio, Stefano ^{[10
]}

Lo Giudice, Francesco ^{[11
]}

Grunig, Ekkehard ^{[12
]}

Haddad, Francois ^{[13
]}

Howard, Luke ^{[11
]}

Rajagopal, Sudarshan ^{[4
]}

Stens, Niels ^{[8
,14
]}

Stolfo, Davide ^{[15
,16
]}

Thijssen, Dick H. J. ^{[14
,17
]}

Vizza, Carmine Dario ^{[6
]}

Zamanian, Roham T. ^{[13
,18
]}

Zhong, Liang ^{[19
,20
]}

Seeger, Werner ^{[1
]}

Ghofrani, Hossein A. ^{[1
,21
]}

Tello, Khodr ^{[1
]}

机构：

[1] Univ Giessen & Marburg Lung Ctr UGMLC, Justus Liebig Univ, Cardiopulmo nary Inst CPI, Inst Lung Hlth ILH,Dept Internal Med, Giessen, Germany

[2] San Giovanni Battista Hosp, Dept Cardiol ogy, Foligno, Italy

[3] Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands

[4] Duke Univ Med Ctr, Dept Med, Div Cardiol, Durham, NC USA

[5] Univ Naples 2, Monaldi Hosp, Cardiol, Naples, Italy

[6] Sapienza Univ Rome, Dept Cardiovasc & Resp Sci, Rome, Italy

[7] Univ British Columbia, Div Cardiol, Vancouver, BC, Canada

[8] Radboud Univ Nijmegen Med Ctr, Res Inst Hlth Sci, Dept Cardiol, Nijmegen, Netherlands

[9] Med Univ Graz, Dept Internal Med, Div Pulmonol, Graz, Austria

[10] Fdn IRCCS Policlin San Matteo, Div Cardiol, Pavia, Italy

[11] Hammersmith Hosp, Dept Cardiol, Natl Pulm Hypertens Serv, Imperial Col lege NHS Trust, London, England

[12] Thoraxclin Heidelberg GmbH Heidelberg Univ Hosp, Ctr Pulm Hypertens, Heidelberg, Germany

[13] Stanford Univ, Div Cardiovasc Med, Sch Med, Stanford, CA USA

[14] Radboud Univ Nijmegen, Res Inst Hlth Sci, Dept Physiol, Med Ctr, Nijmegen, Netherlands

[15] Azienda Sanit Universitaria Integrata, Dept Cardiol, Trieste, Italy

[16] Karolinska Inst, Dept Med, Div Cardiol, Stockholm, Sweden

[17] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Lancashire, England

[18] Stanford Univ, Vera Moulton Wall Ctr Pulm Vasc Dis, Stanford, CA USA

[19] Natl Univ Singapore, Natl Heart Ctr Singapore, Duke NUS Med Sch, Singapore, Singapore

[20] Duke NUS Med Sch, Res Cardiovasc & Metab Disorders, Singapore, Singapore

[21] Imperial Coll London, Dept Med, London, England

[22] Justus Liebig Univ Giessen, Dept Internal Med, Klinikstrasse 32, D-35392 Giessen, Germany

来源：

JOURNAL OF HEART AND LUNG TRANSPLANTATION | 2023年 / 42卷 / 04期

关键词：

Imaging; meta-analysis; right atrium; pulmonary hypertension; outcome; systematic review; ARTERIAL-HYPERTENSION; EUROPEAN-ASSOCIATION; AMERICAN-SOCIETY; PROGNOSTIC VALUE; RIGHT HEART; ECHOCARDIOGRAPHY; PREDICTORS; GUIDELINES; FRACTION; OUTCOMES;

D O I：

10.1016/j.healun.2022.11.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND: Right atrial (RA) imaging has emerged as a promising tool for the evaluation of patients with pulmonary hypertension (PH), albeit without systematic validation.METHODS: PubMed, Web of Science and the Cochrane library were searched for studies investigating the prognostic value of RA imaging assessment in patients with PH from 2000 to June 2021 (PROSPERO Identifier: CRD42020212850). An inverse variance-weighted meta-analysis of univari-able hazard ratios (HRs) was performed using a random effects model.RESULTS: Thirty-five studies were included (3,476 patients with PH; 74% female, 86% pulmonary arte-rial hypertension). Risk of bias was low/moderate (Quality of Prognosis Studies checklist). RA area (HR 1.06; 95% confidence interval [CI] 1.04-1.08), RA indexed area (HR 1.09; 95% CI 1.04-1.14), RA peak longitudinal strain (PLS; HR 0.94; 95% CI 0.91-0.97) and RA total emptying fraction (HR 0.96; 95% CI 0.94-0.98) were significantly associated with combined end-points including death, clinical worsening and/or lung transplantation; RA volume and volume index showed marginal significant associations. RA area (HR 1.06; 95% CI 1.04-1.07), RA indexed area (HR 1.12; 95% CI 1.07-1.17) and RA PLS (HR 0.98; 95% CI 0.97-0.99) showed significant associations with mortality; RA total emptying fraction showed a marginal association.CONCLUSIONS: Imaging-based RA assessment qualifies as a relevant prognostic marker in PH. RA area reliably predicts composite end-points and mortality, which underscores its clinical utility. RA PLS emerged as a promising imaging measure, but is currently limited by the number of studies and differ-ent acquisition methods.J Heart Lung Transplant 2023;42:433-446 (c) 2022 International Society for Heart and Lung Transplantation. All rights reserved.

引用

页码：433 / 446

页数：14

共 62 条

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