Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies

被引：196

作者：

Haynes, Barton F. ^{[1
,2
,3
]}

Wiehe, Kevin ^{[1
,2
]}

Borrrow, Persephone ^{[4
]}

Saunders, Kevin O. ^{[1
,5
]}

Korber, Bette ^{[6
,7
]}

Wagh, Kshitij ^{[6
,7
]}

McMichael, Andrew J. ^{[4
]}

Kelsoe, Garnett ^{[1
,3
,5
]}

Hahn, Beatrice H. ^{[8
,9
]}

Alt, Frederick ^{[10
]}

Shaw, George M. ^{[8
,9
]}

机构：

[1] Duke Univ, Sch Med, Duke Human Vaccine Inst, Durham, NC 27706 USA

[2] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA

[3] Duke Univ, Sch Med, Dept Immunol, Durham, NC 27706 USA

[4] Univ Oxford, Nuffield Dept Clin Med, Oxford, England

[5] Duke Univ, Dept Surg, Sch Med, Durham, NC USA

[6] Los Alamos Natl Lab, T6 Theoret Biol & Biophys, Los Alamos, NM USA

[7] New Mexico Consortium, Los Alamos, NM USA

[8] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[9] Univ Penn, Dept Microbiol, Philadelphia, PA 19104 USA

[10] Harvard Med Sch, Program Cellular & Mol Med, Boston Childrens Hosp, Dept Genet,Howard Hughes Med Inst, Boston, MA USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2023年 / 23卷 / 03期

基金：

美国国家卫生研究院;

关键词：

RETROVIRUSES HTLV-III; B-CELL RESPONSES; RECOMBINANT GLYCOPROTEIN-120 VACCINE; EFFICACY TRIAL; DOUBLE-BLIND; GERMINAL CENTER; POTENT NEUTRALIZATION; AFFINITY MATURATION; MONOCLONAL-ANTIBODY; MEDIATED-IMMUNITY;

D O I：

10.1038/s41577-022-00753-w

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and durable HIV-1 vaccine is challenging, including the extraordinary genetic diversity of HIV-1 and its complex mechanisms of immune evasion. HIV-1 envelope glycoproteins are poorly recognized by the immune system, which means that potent broadly neutralizing antibodies (bnAbs) are only infrequently induced in the setting of HIV-1 infection or through vaccination. Thus, the biology of HIV-1-host interactions necessitates novel strategies for vaccine development to be designed to activate and expand rare bnAb-producing B cell lineages and to select for the acquisition of critical improbable bnAb mutations. Here we discuss strategies for the induction of potent and broad HIV-1 bnAbs and outline the steps that may be necessary for ultimate success. There are many reasons why the development of a potent and durable vaccine to HIV-1 is exceptionally challenging, including the large genetic diversity of the virus and its complex mechanisms of immune evasion. In this Review, Haynes et al. discuss strategies for the induction of potent broadly neutralizing antibodies for HIV-1 and the steps that may be necessary for ultimate success.

引用

页码：142 / 158

页数：17

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