Lacosamide in trigeminal neuralgia: report of a case refractory to first- and second-generation anticonvulsants

被引：10

作者：

Adamo, Daniela ^{[1
]}

Coppola, Noemi ^{[1
]}

Pecoraro, Giuseppe ^{[1
]}

Nicolo, Michele ^{[1
]}

Mignogna, Michele Davide ^{[1
]}

机构：

[1] Univ Federico II Naples, Dept Neurosci Reprod & Odontostomatol Sci, I-80131 Naples, Italy

来源：

CRANIO-THE JOURNAL OF CRANIOMANDIBULAR & SLEEP PRACTICE | 2023年 / 41卷 / 02期

关键词：

Trigeminal neuralgia; lacosamide; leukopenia; side effects; facial pain; NEUROPATHIC PAIN; DOUBLE-BLIND; DRUG; EPILEPSY; SAFETY;

D O I：

10.1080/08869634.2020.1804233

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Background The treatment of trigeminal neuralgia (TN) involves first- and second-generation anticonvulsants. However, side effects (SEs) impair compliance with treatment, especially in elderly patients. Lacosamide (LCM) is a third-generation anticonvulsant with a mechanism of action that is not completely clear. It has few SEs and has been considered in the treatment of neuropathic pain. Clinical Presentation LCM was prescribed as a monotherapy for a 60-year-old female with TN who had proven refractory to previous treatments in terms of both the absence of any pain relief and the appearance of severe leukopenia. The treatment dosage was 100 mg twice daily. Pain relief was obtained after three weeks of treatment without any SEs. Currently, the patient takes a maintenance dosage of 100 mg/daily, remaining in a state of complete well-being. Conclusion LCM has shown evidence of a potential efficacy and a good safety profile in the treatment of this patient with TN.

引用

页码：126 / 130

页数：5

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