Retrospective Analyses of PD-L1, LAG-3, TIM-3, OX40L Expressions and MSI Status in Gastroenteropancreatic Neuroendocrine Neoplasms

被引：0

作者：

Gurler, Fatih ^{[1
,8
]}

Esen, Selin Akturk ^{[2
]}

Inci, Bediz Kurt ^{[3
]}

Sutcuoglu, Osman ^{[4
]}

Ucar, Gokhan ^{[2
]}

Akdogan, Orhun ^{[5
]}

Uncu, Dogan ^{[2
]}

Turhan, Nesrin ^{[6
]}

Akyurek, Nalan ^{[7
]}

Ozdemir, Nuriye ^{[4
]}

Ozet, Ahmet ^{[4
]}

Yazici, Ozan ^{[4
]}

机构：

[1] Univ Hlth Sci, Dr Abdurrahman Yurtaslan Oncol Training & Res Hosp, Dept Med Oncol, Ankara, Turkiye

[2] Univ Hlth Sci, Ankara City Hosp, Dept Med Oncol, Ankara, Turkiye

[3] Aksaray Training & Res Hosp, Dept Med Oncol, Aksaray, Turkiye

[4] Gazi Univ, Sch Med, Dept Med Oncol, Ankara, Turkiye

[5] Yenimahalle Training & Res Hosp, Dept Internal Med, Ankara, Turkiye

[6] Univ Hlth Sci, Ankara City Hosp, Dept Pathol, Ankara, Turkiye

[7] Gazi Univ, Sch Med, Dept Pathol, Ankara, Turkiye

[8] Univ Hlth Sci, Dr Abdurrahman Yurtaslan Oncol Training & Res Hosp, Dept Med Oncol, Yenimahalle Ankara, Turkiye

来源：

CANCER INVESTIGATION | 2024年 / 42卷 / 02期

关键词：

PD-L1; LAG-3; TIM-3; OX40L; MSI; TUMOR-INFILTRATING LYMPHOCYTES; MICROSATELLITE INSTABILITY; PHASE-II; CANCER; PATHWAYS; EFFICACY; PROTEIN; SAFETY; CD223;

D O I：

10.1080/07357907.2024.2330102

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated expressions of PD-L1, LAG-3, TIM-3, and OX40L as immune checkpoint proteins, and MSI (repetitive short-DNA-sequences due to defective DNA-repair system) status were analyzed with immunohistochemistry from tissue blocks. Of 83 patients, PD-L1 expression was observed in 18.1% (n = 15) of the patients. None of the patients exhibited LAG-3 expression. TIM-3 expression was 4.9% (n = 4), OX40L was 22.9% (n = 19), and 8.4% (n = 7) of the patients had MSI tumor. A low-to-intermediate positive correlation was observed between PD-L1 and TIM-3 expressions (rho: 0.333, p < 0.01). Although PD-L1 expression was higher in grade 3 NET/NEC, MSI status was prominent in grade 1/2 NET.

引用

页码：141 / 154

页数：14

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