Janus Kinase 3 (JAK3): A Critical Conserved Node in Immunity Disrupted in Immune Cell Cancer and Immunodeficiency

被引：2
|
作者：
Liongue, Clifford [1 ,2 ]
Ratnayake, Tarindhi [1 ]
Basheer, Faiza [1 ,2 ]
Ward, Alister C. [1 ,2 ]
机构：
[1] Deakin Univ, Sch Med, Geelong, Vic 3216, Australia
[2] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat IMPACT, Geelong, Vic 3216, Australia
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 05期
关键词：
cytokine; cytokine receptor; immunity; immunodeficiency; JAK3; leukemia; ACUTE MEGAKARYOBLASTIC LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; STAT PATHWAY; STEM-CELL; ACTIVATING MUTATIONS; DEFICIENCY; RECEPTOR; CYTOKINE; INTERLEUKIN-2; FAMILY;
D O I：
10.3390/ijms25052977
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Janus kinase (JAK) family is a small group of protein tyrosine kinases that represent a central component of intracellular signaling downstream from a myriad of cytokine receptors. The JAK3 family member performs a particularly important role in facilitating signal transduction for a key set of cytokine receptors that are essential for immune cell development and function. Mutations that impact JAK3 activity have been identified in a number of human diseases, including somatic gain-of-function (GOF) mutations associated with immune cell malignancies and germline loss-of-function (LOF) mutations associated with immunodeficiency. The structure, function and impacts of both GOF and LOF mutations of JAK3 are highly conserved, making animal models highly informative. This review details the biology of JAK3 and the impact of its perturbation in immune cell-related diseases, including relevant animal studies.
引用
收藏
页数：13
相关论文
共 37 条
  • [21] JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation
    Rodriguez, Georgialina
    Martinez, George Steven
    Negrete, Omar Daniel
    Sun, Shengjie
    Guo, Wenhan
    Xie, Yixin
    Li, Lin
    Xiao, Chuan
    Ross, Jeremy Aaron
    Kirken, Robert Arthur
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (15)
  • [22] Design, synthesis and structure-activity relationship studies of pyrido [2,3-d]pyrimidin-7-ones as potent Janus Kinase 3 (JAK3) covalent inhibitors
    Su, Wenhong
    Chen, Zhiwen
    Liu, Meiying
    He, Rui
    Liu, Chaoyi
    Li, Rui
    Gao, Mingshan
    Zheng, Mingyue
    Tu, Zhengchao
    Zhang, Zhang
    Xu, Tianfeng
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2022, 64
  • [23] Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment
    Cattaneo, Federica
    Recher, Mike
    Masneri, Stefania
    Baxi, Sachin N.
    Fiorini, Claudia
    Antonelli, Francesca
    Wysocki, Christian A.
    Calderon, Jose G.
    Eibel, Hermann
    Smith, Angela R.
    Bonilla, Francisco A.
    Tsitsikov, Erdyni
    Giliani, Silvia
    Notarangelo, Luigi D.
    Pai, Sung-Yun
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2013, 131 (04) : 1136 - 1145
  • [24] In silico discovery of potent and selective Janus kinase 3 (JAK3) inhibitors through 3D-QSAR, covalent docking, ADMET analysis, molecular dynamics simulations, and binding free energy of pyrazolopyrimidine derivatives
    Faris, Abdelmoujoud
    Hadni, Hanine
    Ibrahim, Ibrahim M.
    Elhallaoui, Menana
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, : 4817 - 4833
  • [25] Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications
    Li, Shuyu D.
    Ma, Meng
    Li, Hui
    Waluszko, Aneta
    Sidorenko, Tatyana
    Schadt, Eric E.
    Zhang, David Y.
    Chen, Rong
    Ye, Fei
    GENOME MEDICINE, 2017, 9
  • [26] Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications
    Li S.D.
    Ma M.
    Li H.
    Waluszko A.
    Sidorenko T.
    Schadt E.E.
    Zhang D.Y.
    Chen R.
    Ye F.
    Genome Medicine, 9 (1)
  • [27] Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts
    Paniagua, R
    Si, MS
    Flores, MG
    Rousvoal, G
    Zhang, S
    Aalami, O
    Campbell, A
    Changelian, PS
    Reitz, BA
    Borie, DC
    TRANSPLANTATION, 2005, 80 (09) : 1283 - 1292
  • [28] Novel 1H-pyrazolo[3,4-d]pyrimidin-6-amino derivatives as potent selective Janus kinase 3 (JAK3) inhibitors. Evaluation of their improved effect for the treatment of rheumatoid arthritis
    Yin, Yuan
    Chen, Cheng-Juan
    Yu, Ru-Nan
    Shu, Lei
    Wang, Zhi-Jian
    Zhang, Tian-Tai
    Zhang, Da-Yong
    BIOORGANIC CHEMISTRY, 2020, 98
  • [29] Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis
    Smirnova, T.
    Zhou, Z. N.
    Flinn, R. J.
    Wyckoff, J.
    Boimel, P. J.
    Pozzuto, M.
    Coniglio, S. J.
    Backer, J. M.
    Bresnick, A. R.
    Condeelis, J. S.
    Hynes, N. E.
    Segall, J. E.
    ONCOGENE, 2012, 31 (06) : 706 - 715
  • [30] A case of aberrant CD8 T cell–restricted IL-7 signaling with a Janus kinase 3 defect–associated atypical severe combined immunodeficiency
    Aaruni Khanolkar
    Jeffrey D. Wilks
    Guorong Liu
    Bridget M. Simpson
    Edward A. Caparelli
    Dawn A. Kirschmann
    Jenna Bergerson
    Ramsay L. Fuleihan
    Immunologic Research, 2020, 68 : 13 - 27
1234