Effects of guanidinoacetic acid supplementation on liver and breast muscle fat deposition, lipid levels, and lipid metabolism-related gene expression in ducks

被引:2
|
作者
Wu, Hongzhi [1 ]
Xie, Jiajun [2 ]
Peng, Weiqi [1 ]
Ji, Fengjie [1 ]
Qian, Jinyu [1 ]
Shen, Qian [3 ]
Hou, Guanyu [1 ]
机构
[1] Chinese Acad Trop Agr Sci, Trop Crop Genet Resource Res Inst, Haikou, Peoples R China
[2] Northeast Agr Univ, Coll Anim Sci & Technol, Harbin, Peoples R China
[3] Hainan Xuhuai Technol Co Ltd, Haikou, Peoples R China
基金
海南省自然科学基金;
关键词
guanidinoacetic acid; fat deposition; lipase activity; fatty acid composition; lipid metabolism genes; HIGH-DENSITY-LIPOPROTEIN; EXCHANGEABLE APOLIPOPROTEINS; CARCASS CHARACTERISTICS; LDL RECEPTOR; PERFORMANCE; LIPASE; INSIGHTS; CREATINE;
D O I
10.3389/fvets.2024.1364815
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Exogenous supplementation of guanidinoacetic acid can mechanistically regulate the energy distribution in muscle cells. This study aimed to investigate the effects of guanidinoacetic acid supplementation on liver and breast muscle fat deposition, lipid levels, and lipid metabolism-related gene expression in ducks. We randomly divided 480 42 days-old female Jiaji ducks into four groups with six replicates and 20 ducks for each replicate. The control group was fed the basal diet, and the experimental groups were fed the basal diet with 400, 600, and 800 mg/kg (GA400, GA600, and GA800) guanidinoacetic acid, respectively. Compared with the control group, (1) the total cholesterol (p = 0.0262), triglycerides (p = 0.0357), malondialdehyde (p = 0.0452) contents were lower in GA400, GA600 and GA800 in the liver; (2) the total cholesterol (p = 0.0365), triglycerides (p = 0.0459), and malondialdehyde (p = 0.0326) contents in breast muscle were decreased in GA400, GA600 and GA800; (3) the high density lipoprotein (p = 0.0356) and apolipoprotein-A1 (p = 0.0125) contents were increased in GA600 in the liver; (4) the apolipoprotein-A1 contents (p = 0.0489) in breast muscle were higher in GA600 and GA800; (5) the lipoprotein lipase contents (p = 0.0325) in the liver were higher in GA600 and GA800; (6) the malate dehydrogenase contents (p = 0.0269) in breast muscle were lower in GA400, GA600, and GA800; (7) the insulin induced gene 1 (p = 0.0326), fatty acid transport protein 1 (p = 0.0412), and lipoprotein lipase (p = 0.0235) relative expression were higher in GA400, GA600, and GA800 in the liver; (8) the insulin induced gene 1 (p = 0.0269), fatty acid transport protein 1 (p = 0.0234), and lipoprotein lipase (p = 0.0425) relative expression were increased in GA400, GA600, and GA800 in breast muscle. In this study, the optimum dosage of 600 mg/kg guanidinoacetic acid improved the liver and breast muscle fat deposition, lipid levels, and lipid metabolism-related gene expression in ducks.
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页数:11
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