Ferroptosis: Promising approach for cancer and cancer immunotherapy

被引：37
作者：
Zheng, Shuyue [1 ,2 ]
Guan, Xin-Yuan [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Univ Hong Kong, Li Ka Shing Fac Med, Dept Clin Oncol, Hong Kong, Peoples R China
[2] Univ Hong Kong Shenzhen Hosp, Dept Clin Oncol, Shenzhen, Peoples R China
[3] Sun Yat Sen Univ, State Key Lab Oncol Southern China, Ctr Canc, Guangzhou, Peoples R China
[4] Jinan Univ, Key Lab Tumor Mol Biol, MOE, Guangzhou, Guangdong, Peoples R China
[5] Adv Nucl Energy & Nucl Technol Res Ctr, Adv Energy Sci & Technol Guangdong Lab, Huizhou, Guangdong, Peoples R China
来源：
CANCER LETTERS | 2023年 / 561卷
基金：
中国国家自然科学基金;
关键词：
Ferroptosis; Tumor microenvironment; Immunotherapy; MEDIATED FERROPTOSIS; CELL-DEATH; TP53; GENE; IRON; METABOLISM; IMMUNITY; PEROXIDATION; MACROPHAGES; SUPPRESSION; REPRESSION;
D O I：
10.1016/j.canlet.2023.216152
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ferroptosis is the cell death induced by ferrous ions and lipid peroxidation accumulation in tumor cells. Targeting ferroptosis, which is regulated by various metabolic and immune elements, might become a novel strategy for anti-tumor therapy. In this review, we will focus on the mechanism of ferroptosis and its interaction with cancer and tumor immune microenvironment, especially for the relationship between immune cells and ferroptosis. Also, we will discuss the latest preclinical progress of the collaboration between the ferroptosis-targeted drugs and immunotherapy, and the best potential conditions for their combined use. It will present a future insight on the possible value of ferroptosis in cancer immunotherapy.
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页数：9
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