Novel Bis-pyrazoline Fluorescent Probe for Cu2+ and Fe3+ Detection and Application in Cell Imaging

被引：9
作者：
Yang, Yun-Shang [1 ,2 ]
Wang, Fu-Nian [1 ,2 ]
Zhang, Ying-Peng [1 ,2 ]
Yang, Feng [1 ,2 ]
Xue, Ji-Jun [3 ,4 ]
机构：
[1] Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou 730050, Peoples R China
[2] Lanzhou Univ Technol, Key Lab Low Carbon Energy & Chem Engn Gansu, Lanzhou 730050, Peoples R China
[3] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
[4] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China
来源：
JOURNAL OF FLUORESCENCE | 2024年 / 34卷 / 01期
关键词：
Pyrazoline; Fluorescent probe; Copper ions; Iron ion sensor; RECENT PROGRESS; PHOTOPHYSICAL PROPERTIES; CHEMOSENSOR; ZN2+; COPPER; IONS; ACID; DERIVATIVES; SENSOR;
D O I：
10.1007/s10895-023-03213-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A fluorescent probe Y((1,1'-([1,1'-biphenyl]-4,4'-diylbis(3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-5,1-diyl)) bis(ethan-1-one))) was designed and synthesized, which could be used to Cu2+ and Fe3+ sensors. Through the study of optical properties, the probe Y shows good selectivity and sensitivity to Cu2+ and Fe3+ in aqueous tetrahydrofuran solution [10.0 mM HEPES, pH 7.4, THF-H2O = 9:1(v/v)] with has excellent anti-interference performance, and its detection limits were 0.931 uM for Cu2+ and 0.401uM for Fe3+. The coordination mechanism of probe Y with Cu2+ and Fe3+ was speculated and verified at DFT level and HRNM. By Hela cytotoxicity and imaging tests, probe Y not only has good biocompatibility, but also can be used for sensing Cu2+ in cells.
引用
收藏
页码：159 / 167
页数：9
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