Five glycosylated phenolic derivatives from the bark of Ilex rotunda Thunb. and their anti-inflammatory activities

被引：1

作者：

Peng, Shou ^{[1
,2
]}

Chen, Tong ^{[1
]}

Wang, Ge ^{[1
,2
]}

Li, Chen-yue ^{[1
,2
]}

Liu, Wen-jing ^{[3
]}

Wang, Wen-qiong ^{[1
]}

Xuan, Li-jiang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Medica, State Key Lab Drug Res, Shanghai, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 04期

关键词：

Ilex rotunda; hemiterpene glycosides; phenolic glycosides; anti-inflammatory activity; INFLAMMATORY MEDIATORS; KERATINOCYTES; CONSTITUENTS; GLYCOSIDES; AKT;

D O I：

10.1080/14786419.2022.2078323

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Five new glycosylated phenolic derivatives, rotundosides A-E (1-5), and three known glycosides (6-8) were isolated from the 95% alcohol extract of the bark of Ilex rotunda. Their structures were elucidated by extensive spectroscopic analysis and comparison with the literature data. All new compounds possessed a [5-O-(E)-caffeoyl]-beta-D-apiofuranosyl-(1 -> 6)-beta-D-glucopyranosyl group. The anti-inflammatory properties of all isolated compounds were evaluated using a modified nitric oxide (NO) production in lipopolysaccharide (LPS)-induced leukemia cells in mouse macrophage (RAW264.7) method. Compound 8, dracunculifoside H, showed significant anti-inflammatory activity in vitro.

引用

页码：571 / 578

页数：8

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