Progress of fluorescent probes for protein phosphorylation and glycosylation in atherosclerosis

被引：0

作者：

Li, Jin ^{[1
]}

Xu, Jiheng ^{[2
]}

Zhao, Ruize ^{[1
]}

Zhang, Wei ^{[1
]}

Li, Ping ^{[1
]}

Zhang, Wen ^{[1
]}

Wang, Hui ^{[1
]}

Tang, Bo ^{[1
,3
]}

机构：

[1] Shandong Normal Univ, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci,Inst Biomed Sci, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Peoples R China

[2] Shandong Univ, Sch Mat Sci & Engn, Jinan 250014, Peoples R China

[3] Laoshan Lab, Qingdao 266237, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2024年 / 30卷 / 18期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

atherosclerosis; phosphorylation; glycosylation; fluorescent probe; biomarker; CROSS-TALK; CELL; VISUALIZATION; RECOGNITION; RECEPTORS; DISEASES; PEPTIDE;

D O I：

10.1002/chem.202303778

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Exploring the post-translational modification (PTM) of proteins in the course of atherosclerotic disease has important guiding significance for the early warning of atherosclerotic plaque, the development of targeted drugs and the treatment of disease. The advancement advanced detection and imaging methods for phosphorylated and glycosylated proteins is an important tool to further reveal the levels of protein phosphorylation and glycosylation during atherosclerotic plaque formation. We present research strategies for detecting protein phosphorylation and glycosylation from the perspective of fluorescent probes, and discuss the feasibility and future direction of the development of these methods for detecting and imaging phosphorylated and glycosylated proteins in atherosclerotic disease. Exploring the post-translational modification (PTM) of proteins in the course of atherosclerotic disease has important guiding significance for the early warning of atherosclerotic plaque and the development of targeted drugs. We present strategies for detecting protein phosphorylation and glycosylation from the perspective of fluorescent probes, and discuss the problems and future directions of these methods+image

引用

页数：9

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