Experimental infection of tick cells with Nipah virus

被引：0

作者：

Phoon, W. H. ^{[1
]}

Bell-Sakyi, L. ^{[2
]}

AbuBakar, S. ^{[3
]}

Chang, L. Y. ^{[1
]}

机构：

[1] Univ Malaya, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia

[2] Univ Liverpool, Inst Infect Vet & Ecol Sci, 146 Brownlow Hill, Liverpool L3 5RF, England

[3] Univ Malaya, Trop Infect Dis Res & Educ Ctr, Kuala Lumpur 50603, Malaysia

来源：

TROPICAL BIOMEDICINE | 2023年 / 40卷 / 01期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Henipavirus infection; Chiroptera; ticks; viral RNA; electron microscopy; HENDRA VIRUS; OUTBREAK; BATS; ENCEPHALITIS; TRANSMISSION; REPLICATION; LINES;

D O I：

10.47665/tb.40.1.009

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Nipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tick cells and ultrastructural features of NiV were observed by electron microscopy. These results suggest that ticks could support NiV infection, potentially playing a role in transmission.

引用

页码：29 / 36

页数：8