Cost-related prescription non-adherence and patient-reported outcomes in systemic lupus erythematosus: The Michigan Lupus Epidemiology & Surveillance program

被引：4

作者：

Minhas, Deeba ^{[1
]}

Marder, Wendy ^{[1
,2
]}

Hassett, Afton L. ^{[3
]}

Zick, Suzanna M. ^{[4
]}

Gordon, Caroline ^{[5
]}

Harlow, Sioban D. ^{[6
]}

Wang, Lu ^{[7
]}

Barbour, Kamil E. ^{[8
]}

Helmick, Charles G. ^{[8
]}

McCune, W. Joseph ^{[1
]}

Somers, Emily C. ^{[1
,2
,9
,10
,11
]}

机构：

[1] Univ Michigan, Dept Internal Med, Ann Arbor, MI USA

[2] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI USA

[3] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI USA

[4] Univ Michigan, Dept Family Med, Ann Arbor, MI USA

[5] Univ Birmingham, Inst Inflammat & Ageing, Rheumatol Res Grp, Birmingham, England

[6] Univ Michigan, Dept Epidemiol, Ann Arbor, MI USA

[7] Univ Michigan, Dept Biostat, Ann Arbor, MI USA

[8] CDCP, Atlanta, GA USA

[9] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI USA

[10] Univ Michigan, Med Environm Hlth & Obstet & Gynecol, Sch Med, 2800 Plymouth Rd,NCRC B14-G236, Ann Arbor, MI 48109 USA

[11] Univ Michigan, Med Environm Hlth & Obstet & Gynecol, Sch Publ Hlth, 2800 Plymouth Rd,NCRC B14-G236, Ann Arbor, MI 48109 USA

来源：

LUPUS | 2023年 / 32卷 / 09期

关键词：

Lupus; patient-reported outcomes; epidemiology; health services research; prescriptions; non-adherence; MEDICATION NONADHERENCE; RACIAL DISPARITIES; HEALTH OUTCOMES; ADHERENCE; MORTALITY; GENDER; PREVALENCE; VALIDATION; ETHNICITY; DISEASE;

D O I：

10.1177/09612033231186113

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives Medication access and adherence play key roles in determining patient outcomes. We investigated whether cost-related non-adherence (CRNA) to prescription medications was associated with worse patient-reported outcomes in a population-based systemic lupus erythematosus (SLE) cohort. Methods Sociodemographic and prescription data were collected by structured interviews in 2014-2015 from patients meeting SLE criteria in the established Michigan Lupus Epidemiology & Surveillance (MILES) Cohort. We examined the associations between CRNA and potential confounders such as sociodemographics and health insurance coverage, and outcome measures of SLE activity and damage using multivariable linear regression. Results 462 SLE participants completed the study visit: 430 (93.1%) female, 208 (45%) Black, and mean age 53.3 years. 100 (21.6%) participants with SLE reported CRNA in the preceding 12 months. After adjusting for covariates, CRNA was associated with both higher levels of current SLE disease activity [SLAQ: & beta; coeff 2.7 (95% CI 1.3, 4.1), p < 0.001] and damage [LDIQ & beta; coeff 1.4 (95% CI 0.5, 2.4), p = 0.003]. Race, health insurance status, and fulfilling Fibromyalgia (FM) Survey Criteria were independently associated with both higher (worse) SLAQ and LDIQ scores; female sex was further associated with higher SLAQ scores. Conclusion Patients with SLE who reported CRNA in the previous 12 months had significantly worse self-reported current disease activity and damage scores compared to those not reporting CRNA. Raising awareness and addressing barriers or concerns related to financial implications and accessibility issues in care plans may help to improve these outcomes.

引用

页码：1075 / 1083

页数：9

共 52 条

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