An Update on Adipose-Derived Stem Cells for Regenerative Medicine: Where Challenge Meets Opportunity

被引：93
作者：
Qin, Yi [1 ]
Ge, Gaoran [1 ]
Yang, Peng [1 ]
Wang, Liangliang [2 ]
Qiao, Yusen [1 ]
Pan, Guoqing [3 ]
Yang, Huilin [1 ]
Bai, Jiaxiang [1 ]
Cui, Wenguo [4 ]
Geng, Dechun [1 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Orthopaed Inst, Med Coll,Dept Orthopaed, Suzhou 215006, Jiangsu, Peoples R China
[2] Nanjing Med Univ, Dept Orthopaed, Affiliated Changzhou Peoples Hosp 2, Changzhou 213000, Jiangsu, Peoples R China
[3] Jiangsu Univ, Inst Adv Mat, Sch Mat Sci & Engn, Zhenjiang 212013, Jiangsu, Peoples R China
[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed,Sch Med, Dept Orthopaed,Shanghai Key Lab Prevent & Treatmen, Shanghai 200025, Peoples R China
来源：
ADVANCED SCIENCE | 2023年 / 10卷 / 20期
基金：
中国国家自然科学基金;
关键词：
3D bioprinting; adipose-derived stem cells; cell-free therapy; clinical application; regenerative medicine; MESENCHYMAL STROMAL CELLS; CARTILAGE EXTRACELLULAR-MATRIX; SCIATIC-NERVE REGENERATION; BONE-MARROW; OSTEOGENIC DIFFERENTIATION; MYOCARDIAL-INFARCTION; INTERNATIONAL-SOCIETY; ASSISTED LIPOTRANSFER; CONDITIONED MEDIUM; VASCULAR FRACTION;
D O I：
10.1002/advs.202207334
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Over the last decade, adipose-derived stem cells (ADSCs) have attracted increasing attention in the field of regenerative medicine. ADSCs appear to be the most advantageous cell type for regenerative therapies owing to their easy accessibility, multipotency, and active paracrine activity. This review highlights current challenges in translating ADSC-based therapies into clinical settings and discusses novel strategies to overcome the limitations of ADSCs. To further establish ADSC-based therapies as an emerging platform for regenerative medicine, this review also provides an update on the advancements in this field, including fat grafting, wound healing, bone regeneration, skeletal muscle repair, tendon reconstruction, cartilage regeneration, cardiac repair, and nerve regeneration. ADSC-based therapies are expected to be more tissue-specific and increasingly important in regenerative medicine.
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页数：27
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