Diphenyl disulfide potentiates the apoptosis of breast cancer cells through Bax proteolytic activation with accompanying autophagy

被引：2

作者：

Chen, Sheng-Yuan ^{[1
]}

Chiu, Chien-Chih ^{[2
,3
,4
,5
,6
]}

Hung, Chun-Tzu ^{[2
]}

Pan, Wen-Hsiung ^{[3
]}

Chen, Yen-Chun ^{[2
]}

Bow, Yung-Ding ^{[7
]}

Li, Wan-Ju ^{[2
]}

Hsu, Sheng-Kai ^{[2
]}

Lin, I-Ling ^{[8
,9
]}

Wen, Zhi-Hong ^{[10
]}

Wu, Chang-Yi ^{[2
,3
]}

机构：

[1] Kaohsiung Armed Forces Gen Hosp, Dept Med, Div Cardiol, Zuoying Branch, Kaohsiung, Taiwan

[2] Kaohsiung Med Univ, Dept Biotechnol, Kaohsiung, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung, Taiwan

[4] Kaohsiung Med Univ, Ctr Canc Res, Kaohsiung, Taiwan

[5] Natl Lab Anim Ctr, Natl Appl Res Labs, Taipei, Taiwan

[6] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan

[7] Kaohsiung Med Univ, Coll Life Sci, Ph D Program Life Sci, Kaohsiung, Taiwan

[8] Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan

[9] Kaohsiung Med Univ Hosp, Dept Lab Med, Kaohsiung, Taiwan

[10] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Res, Kaohsiung, Taiwan

来源：

ENVIRONMENTAL TOXICOLOGY | 2023年 / 38卷 / 08期

关键词：

apoptosis; autophagy; breast cancer; chemoresistance; diphenyl disulfide; BCL-2/BAX RATIO; CHEMOTHERAPY; MITOCHONDRIA; REGULATORS;

D O I：

10.1002/tox.23828

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Breast cancer is a leading cause of cancer-related death worldwide, and chemoresistance often leads to poor patient outcomes. In this study, we investigated the anticancer activity of synthetic diphenyl disulfide (DPDS) in breast cancer cell lines. DPDS inhibited cellular proliferation and viability in a dose-dependent manner and reduced colony formation, an index of clonogenicity. Annexin-V and 7-AAD double staining showed that DPDS could induce the apoptosis of breast cancer cells. Western blotting of the expression of Bax p21 and its cleaved form p18 suggested the activation of p18 Bax-induced apoptosis. Furthermore, the increased expression of the autophagy marker LC3B-II indicated autophagic lysosome accumulation induced by DPDS. Our findings suggest that DPDS has potential as a candidate for treating breast cancer, and further modifications and optimizations are warranted.

引用

页码：2022 / 2030

页数：9

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