γδ T cells and their clinical application in colon cancer

被引:10
作者
Corsale, Anna Maria [1 ,2 ,3 ]
Di Simone, Marta [1 ,2 ,3 ]
Lo Presti, Elena [4 ]
Dieli, Francesco [1 ,3 ]
Meraviglia, Serena [1 ,3 ]
机构
[1] Univ Palermo, Cent Lab Adv Diag & Biomed Res CLADIBIOR, Palermo, Italy
[2] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties ProMISE, Palermo, Italy
[3] Univ Palermo, Dept Biomed Nurosci & Adv Diag Bi N D, Palermo, Italy
[4] Natl Res Council CNR I, Inst Biomed Res & Innovat IRIB, Palermo, Italy
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
关键词
gamma delta T cells; immunotherapy; colon rectal cancer; MHC- unrestricted activation; tumor; IMMUNE CELLS; IN-VIVO; IMMUNOTHERAPY; CYTOTOXICITY; RESPONSES; ZOLEDRONATE; RECOGNITION; SECRETION; EXPANSION; EFFICACY;
D O I
10.3389/fimmu.2023.1098847
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In recent years, research has focused on colorectal cancer to implement modern treatment approaches to improve patient survival. In this new era, gamma delta T cells constitute a new and promising candidate to treat many types of cancer because of their potent killing activity and their ability to recognize tumor antigens independently of HLA molecules. Here, we focus on the roles that gamma delta T cells play in antitumor immunity, especially in colorectal cancer. Furthermore, we provide an overview of small-scale clinical trials in patients with colorectal cancer employing either in vivo activation or adoptive transfer of ex vivo expanded gamma delta T cells and suggest possible combinatorial approaches to treat colon cancer.
引用
收藏
页数:10
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