Hypersensitivity reactions to biologics in children

被引：5

作者：

de las Vecillas, Leticia ^{[1
]}

Caimmi, Davide ^{[2
,3
]}

Isabwe, Ghislaine Annie Clarisse ^{[4
]}

Madrigal-Burgaleta, Ricardo ^{[5
,6
]}

Soyer, Ozge ^{[7
]}

Tanno, Luciana ^{[2
,3
,8
]}

Vultaggio, Alessandra ^{[9
]}

Giovannini, Mattia ^{[10
]}

Mori, Francesca ^{[10
]}

机构：

[1] Paz Univ Hosp, IdiPAZ, Dept Allergy, Madrid, Spain

[2] CHU Montpellier, Dept Pulmonol, Allergy Unit, Montpellier, France

[3] Univ Montpellier, IDESP, UMR Inserm, Montpellier, France

[4] McGill Univ Hlth Ctr MUHC, Dept Med, Div Allergy & Clin Immunol, Montreal, PQ, Canada

[5] Barts Hlth NHS Trust, St Bartholomews Hosp, Allergy & Severe Asthma Serv, London, England

[6] Bellvitge Univ Hosp, Catalan Inst Oncol, Drug Desensitisat Ctr, Barcelona, Spain

[7] Hacettepe Univ, Fac Med, Dept Pediat Allergy, Ankara, Turkiye

[8] WHO Collaborating Ctr Sci Classificat Support, Montpellier, France

[9] Univ Careggi, Azienda Osped, Florence, Italy

[10] Meyer Childrens Univ Hosp, Dept Pediat, Florence, Italy

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2023年 / 23卷 / 01期

关键词：

Biologics; drug allergy; biological drugs; pediatrics; IgE-mediated; non-IgE-mediated reactions; anti-drug antibodies; complement activation; drug desensitization; precision medicine; INFLAMMATORY-BOWEL-DISEASE; IN-VITRO; DRUG HYPERSENSITIVITY; DESENSITIZATION; INFLIXIMAB; ANTIBODIES; RITUXIMAB; ACTIVATION; MANAGEMENT; INFUSION;

D O I：

10.1080/14712598.2022.2142039

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Introduction Hypersensitivity reactions (HSRs) have been observed with the use of biologics in children. The management of HSRs in children is mainly based on experiences from the adult population. Recently, data from different centers experienced in managing these reactions, including desensitization in children, have been published, allowing clinicians to have an appropriate global overview and compare results. Areas covered This review highlights the published data on hypersensitivity reactions to biologics in children and drug desensitization protocols adapted to the pediatric population. Expert opinion With regard to HSRs to biologics in children, few data are available. Compared with the adult population, there is a lack of knowledge in the endophenotypes, management and the standardization of protocols including premedication regimens in children. An international consensus is needed to provide clinicians with new insight on how to apply personalized management and to perform tailored desensitization protocols in pediatric populations. Various specialists including allergists, pediatricians, oncologists, hematologists, rheumatologists, and pharmacists, should build a multidisciplinary management team to keep pediatric patients on their best treatment options in the safest manner.

引用

页码：61 / 72

页数：12

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