Modulatory effects of policosanol from insect wax on lipid metabolism in high-fat diet-fed rats

被引：4

作者：

Li, Xian ^{[1
]}

Zhang, Xin ^{[1
]}

Ma, Chenjing ^{[1
]}

Sun, Long ^{[1
]}

He, Zhao ^{[1
]}

Gan, Jin ^{[1
]}

Ding, Weifeng ^{[1
]}

Chen, Xiaoming ^{[1
]}

Chen, Hang ^{[1
]}

Feng, Ying ^{[1
]}

机构：

[1] Chinese Acad Forestry, Inst Highland Forest Sci, Key Lab Breeding & Utilizat Resource Insects, Natl Forestry & Grassland Adm, Kunming 650224, Yunnan, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2023年 / 110卷

关键词：

Policosanol; Insect wax; High-fat diet; Lipid metabolism; Lipid modulation; DYSFUNCTION;

D O I：

10.1016/j.jff.2023.105824

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Insect wax is a traditional Chinese medicine, which can be converted into policosanol through a reduction reaction. The efficacy of policosanol from insect wax (PIW) depends on its purity and composition ratio. Plant derived policosanol has a hypolipidemic effect, however, the effects of PIW on serum lipid levels have not yet been clarified. In this study, we investigated the effects of orally administered PIW on lipid metabolism in rats fed a high-fat diet. We found that PIW administration reduced the serum lipid levels of rats fed a high-fat diet, ameliorated body weight gain, and alleviated liver fat accumulation. This effect could be associated with the upregulation of fatty acid breakdown-and lipid metabolism-related genes, Ppar alpha and Ppar beta/delta, downregulation of fatty acid absorption and storage-related genes, Srebp1c, Il6, and Tnf alpha, and an antioxidant effect. These findings suggest the potential utility of PIW for developing functional foods with lipid-lowering capabilities.

引用

页数：11

共 45 条

[1] Policosanol supplementation significantly improves blood pressure among adults: A systematic review and meta-analysis of randomized controlled trials [J].