SARS-CoV-2 and male infertility: from short- to long-term impacts

被引:19
作者
Dai, P. [1 ]
Qiao, F. [1 ]
Chen, Y. [1 ]
Chan, D. Y. L. [2 ]
Yim, H. C. H. [3 ]
Fok, K. L. [4 ,5 ]
Chen, H. [1 ]
机构
[1] Nantong Univ, Inst Reprod Med, Med Sch, Nantong, Peoples R China
[2] Chinese Univ Hong Kong, Dept Obstet & Gynecol, Assisted Reprod Technol Unit, Hong Kong, Peoples R China
[3] UNSW Sydney, Fac Med, Microbiome Res Ctr, Sch Clin Med, St George & Sutherland Campus, Sydney, Australia
[4] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China
[5] Sichuan Univ Chinese Univ Hong, West China Univ Hosp 2, Kong Joint Lab Reprod Med, Chengdu, Peoples R China
基金
国家重点研发计划; 中国国家自然科学基金;
关键词
SARS-CoV-2; Male infertility; Testis; Epididymis; PRACTICES INTERIM RECOMMENDATION; COVID-19; VACCINE; UNITED-STATES; ADVISORY-COMMITTEE; SEMEN PARAMETERS; MALE-FERTILITY; MESSENGER-RNA; CORONAVIRUS; INFECTION; STRESS;
D O I
10.1007/s40618-023-02055-x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose The coronavirus 2019 (COVID-19) pandemic-caused by a new type of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-has posed severe impacts on public health worldwide and has resulted in a total of > 6 million deaths. Notably, male patients developed more complications and had mortality rates similar to 77% higher than those of female patients. The extensive expression of the SARS-CoV-2 receptor and related proteins in the male reproductive tract and the association of serum testosterone levels with viral entry and infection have brought attention to COVID-19's effects on male fertility. Methods The peer-reviewed articles and reviews were obtained by searching for the keywords SARS-CoV-2, COVID-19, endocrine, spermatogenesis, epididymis, prostate, and vaccine in the databases of PubMed, Web of Science and Google Scholar from 2020-2022. Results This review summarizes the effects of COVID-19 on the male reproductive system and investigates the impact of various types of SARS-CoV-2 vaccines on male reproductive health. We also present the underlying mechanisms by which SARS-CoV-2 affects male reproduction and discuss the potentially harmful effects of asymptomatic infections, as well as the long-term impact of COVID-19 on male reproductive health. Conclusion COVID-19 disrupted the HPG axis, which had negative impacts on spermatogenesis and the epididymis, albeit further investigations need to be performed. The development of vaccines against various SARS-CoV-2 variations is important to lower infection rates and long-term COVID risks.
引用
收藏
页码:1491 / 1507
页数:17
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