Long-term expansion of human hematopoietic stem cells

被引：3
|
作者：
Liang, Guixian [1 ,2 ]
Liu, Feng [1 ,2 ,3 ]
机构：
[1] Univ Chinese Acad Sci, Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing 100101, Peoples R China
[2] Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100101, Peoples R China
[3] Shandong Univ, Sch Life Sci, Qingdao 266237, Peoples R China
来源：
CELL REGENERATION | 2023年 / 12卷 / 01期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1186/s13619-023-00163-w
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the clinical application difficult. To gain more functional human HSCs ex vivo, Sakurai et al. established a recombinant-cytokine-free and albumin-free culture system, i.e. PCL-PVAc-PEG-based culture, in combination with 740Y-P, butyzamide and UM171, to improve the long-term expansion of human cord blood HSCs.
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页数：3
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