Case report: Rapid improvements of anorexia nervosa and probable myalgic encephalomyelitis/chronic fatigue syndrome upon metreleptin treatment during two dosing episodes

被引：2

作者：

Hebebrand, Johannes ^{[1
]}

Antel, Jochen ^{[1
]}

von Piechowski, Linda ^{[2
]}

Kiewert, Cordula ^{[3
]}

Stueve, Burkhard ^{[4
,5
]}

Gradl-Dietsch, Gertraud ^{[1
]}

机构：

[1] Univ Duisburg Essen, Univ Hosp Essen, Ctr Translat Neuro & Behav Sci, Dept Child & Adolescent Psychiat Psychosomat & Psy, Essen, Germany

[2] Univ Munster, Univ Hosp Munster, Dept Child & Adolescent Psychiat Psychosomat & Psy, Munster, Germany

[3] Univ Duisburg Essen, Univ Hosp Essen, Dept Pediat 2, Div Pediat Endocrinol & Diabetol, Essen, Germany

[4] Univ Duisburg Essen, Ctr Neuromuscular Disorders, Ctr Translat Neuro & Behav Sci, Dept Pediat Neurol,Univ Hosp Essen, Essen, Germany

[5] DRK Childrens Hosp Siegen, Dept Neuropediat, Siegen, Germany

来源：

FRONTIERS IN PSYCHIATRY | 2023年 / 14卷

关键词：

leptin; muscle; exhaustion; fatigue; depression; sleep quality; LEPTIN LEVELS; MUSCLE; EXPRESSION; ONSET;

D O I：

10.3389/fpsyt.2023.1267495

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A comorbidity of anorexia nervosa (AN) and myalgic encephalomyelitis (ME/CSF) is uncommon. A 17 years-old male adolescent with possible onset of ME/CFS after an Epstein Barr Virus infection (EBV) and later onset of AN during a second period of weight loss was twice treated off-label with metreleptin for 15 and 11 days, respectively. As in previous cases, eating disorder specific cognitions and mood improved. Interestingly, fatigue and post-exertional muscle pain (P-EMP) improved, too. We discuss potential mechanisms. Treatment with metreleptin may prove beneficial in AN and in ME/CSF associated with substantial weight loss.

引用

页数：8

共 50 条

[1]

American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders, V5th, P591, DOI [10.1176/appi.books.9780890423349, DOI 10.1176/APPI.BOOKS.9780890425596]

[2] Rapid amelioration of anorexia nervosa in a male adolescent during metreleptin treatment including recovery from hypogonadotropic hypogonadism [J].

Antel, Jochen ;

Tan, Susanne ;

Grabler, Marvin ;

Ludwig, Christine ;

Lohkemper, Dominik ;

Brandenburg, Tim ;

Barth, Nikolaus ;

Hinney, Anke ;

Libuda, Lars ;

Remy, Miriam ;

Milos, Gabriella ;

Hebebrand, Johannes .

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY, 2022, 31 (10) :1573-1579

[3] Absence of Functional Leptin Receptor Isoforms in the POUND (Leprdb/lb) Mouse Is Associated with Muscle Atrophy and Altered Myoblast Proliferation and Differentiation [J].

Arounleut, Phonepasong ;

Bowser, Matthew ;

Upadhyay, Sunil ;

Shi, Xing-Ming ;

Fulzele, Sadanand ;

Johnson, Maribeth H. ;

Stranahan, Alexis M. ;

Hill, William D. ;

Isales, Carlos M. ;

Hamrick, Mark W. .

PLOS ONE, 2013, 8 (08)

[4]

Blum WF., 1997, Reference ranges of serum leptin, in leptin-the voice of adipose tissue

[5] Olanzapine use as an adjunctive treatment for hospitalized children with anorexia nervosa: Case reports [J].

Boachie, A ;

Goldfield, GS ;

Spettigue, W .

INTERNATIONAL JOURNAL OF EATING DISORDERS, 2003, 33 (01) :98-103

[6]

Carruthers, 2003, J Chronic Fatigue Syndr, V11, P7, DOI [10.1300/J092v11n0102, DOI 10.1300/J092V11N0102]

[7] Myalgic encephalomyelitis: International Consensus Criteria [J].

Carruthers, B. M. ;

van de Sande, M. I. ;

De Meirleir, K. L. ;

Klimas, N. G. ;

Broderick, G. ;

Mitchell, T. ;

Staines, D. ;

Powles, A. C. P. ;

Speight, N. ;

Vallings, R. ;

Bateman, L. ;

Baumgarten-Austrheim, B. ;

Bell, D. S. ;

Carlo-Stella, N. ;

Chia, J. ;

Darragh, A. ;

Jo, D. ;

Lewis, D. ;

Light, A. R. ;

Marshall-Gradisbik, S. ;

Mena, I. ;

Mikovits, J. A. ;

Miwa, K. ;

Murovska, M. ;

Pall, M. L. ;

Stevens, S. .

JOURNAL OF INTERNAL MEDICINE, 2011, 270 (04) :327-338

[8] Might Starvation-Induced Adaptations in Muscle Mass, Muscle Morphology and Muscle Function Contribute to the Increased Urge for Movement and to Spontaneous Physical Activity in Anorexia Nervosa? [J].

Casper, Regina C. .

NUTRIENTS, 2020, 12 (07) :1-13

[9] Increased urge for movement, physical and mental restlessness, fundamental symptoms of restricting anorexia nervosa? [J].

Casper, Regina C. ;

Voderholzer, Ulrich ;

Naab, Silke ;

Schlegl, Sandra .

BRAIN AND BEHAVIOR, 2020, 10 (03)

[10]

Choutka J, 2022, NAT MED, V28, P911, DOI 10.1038/s41591-022-01810-6

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