Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

被引：1
|
作者：
Bhide, Ashlesha [1 ]
Sen, Ayusman [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2023年 / 25卷 / 32期
关键词：
PROMOTES; NEURONS;
D O I：
10.1039/d3cp01480k
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Multiple studies have shown that the activity of alkaline phosphatase (AP) increases during Alzheimer's disease (AD). In this paper, using UV-Visible spectroscopy, we show that this increase in activity is due to its interaction with key components of AD such as amyloid & beta; peptide and acetylcholinesterase. Activity increase also occurs due to high concentrations of acetylcholine and choline. These conditions are present in AD or could occur due to drugs used for treating AD.
引用
收藏
页码：21149 / 21153
页数：5
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