Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

被引：1
|
作者：
Bhide, Ashlesha [1 ]
Sen, Ayusman [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2023年 / 25卷 / 32期
关键词：
PROMOTES; NEURONS;
D O I：
10.1039/d3cp01480k
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Multiple studies have shown that the activity of alkaline phosphatase (AP) increases during Alzheimer's disease (AD). In this paper, using UV-Visible spectroscopy, we show that this increase in activity is due to its interaction with key components of AD such as amyloid & beta; peptide and acetylcholinesterase. Activity increase also occurs due to high concentrations of acetylcholine and choline. These conditions are present in AD or could occur due to drugs used for treating AD.
引用
收藏
页码：21149 / 21153
页数：5
相关论文
共 50 条
  • [21] Flavonoids as inhibitors of bace activity and beta-amyloid peptide aggregation
    Martin-Aragon, S.
    Bermejo-Bescos, P.
    Jimenez, K. L.
    Benedi, J.
    FREE RADICAL RESEARCH, 2008, 42 : S96 - S96
  • [22] Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives
    V. Castelletto
    P. Ryumin
    R. Cramer
    I. W. Hamley
    M. Taylor
    D. Allsop
    M. Reza
    J. Ruokolainen
    T. Arnold
    D. Hermida-Merino
    C. I. Garcia
    M. C. Leal
    E. Castaño
    Scientific Reports, 7
  • [23] Stereoselective interactions of peptide inhibitors with the β-amyloid peptide
    Chalifour, RJ
    McLaughlin, RW
    Lavoie, L
    Morissette, C
    Tremblay, N
    Boulé, M
    Sarazin, P
    Stéa, D
    Lacombe, D
    Tremblay, P
    Gervais, F
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (37) : 34874 - 34881
  • [24] INTRACELLULAR ALKALINE PHOSPHATASE ACTIVITY
    KRUGELIS, EJ
    GENETICS, 1946, 31 (02) : 221 - 221
  • [25] PYROPHOSPHATASE ACTIVITY OF ALKALINE PHOSPHATASE
    CASEY, P
    RUSSELL, RG
    FERNLEY, HN
    BIRKETT, D
    BISAZ, S
    FLEISCH, H
    HELVETICA PHYSIOLOGICA ET PHARMACOLOGICA ACTA, 1967, 25 (02): : 174 - &
  • [26] Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives
    Castelletto, V.
    Ryumin, P.
    Cramer, R.
    Hamley, I. W.
    Taylor, M.
    Allsop, D.
    Reza, M.
    Ruokolainen, J.
    Arnold, T.
    Hermida-Merino, D.
    Garcia, C. I.
    Leal, M. C.
    Castano, E.
    SCIENTIFIC REPORTS, 2017, 7
  • [27] ALKALINE PHOSPHATASE ACTIVITY AND DIET
    ROSS, MH
    BATT, WG
    JOURNAL OF NUTRITION, 1956, 60 (01): : 137 - 144
  • [28] INCREASE IN ALKALINE-PHOSPHATASE ACTIVITY IN LIVER OF MICE BEARING EHRLICH ASCITES TUMOR
    KOJIMA, Y
    SAKURADA, T
    CANCER RESEARCH, 1976, 36 (01) : 23 - 27
  • [29] INCREASE IN ALKALINE-PHOSPHATASE ACTIVITY IN EMBRYONAL CARCINOMA F9-CELLS
    OZAWA, K
    AKIBA, K
    NAKANISHI, N
    HIRAYAMA, K
    SATO, N
    SUZUKI, H
    GOTO, H
    YAMADA, S
    JOURNAL OF DENTAL RESEARCH, 1987, 66 (04) : 930 - 930
  • [30] Essential amino acids increase the growth and alkaline phosphatase activity in osteoblasts cultured in vitro
    Conconi, MT
    Tommasini, M
    Muratori, E
    Parnigotto, PP
    FARMACO, 2001, 56 (10): : 755 - 761
12345