Self-Assembly of the Tetraphenylethylene-Capped Diserine through a Hierarchical Assembly Process

被引：1

作者：

Chang, Jui-Wen ^{[2
]}

Chakravarthy, Rajan Deepan ^{[2
]}

Chu, Nien-Tzu ^{[2
]}

Liu, Jyun-Cheng ^{[1
]}

Yeh, Mei-Yu ^{[1
]}

Lin, Hsin-Chieh ^{[2
]}

机构：

[1] Chung Yuan Christian Univ, Dept Chem, Zhongli 320314, Taiwan

[2] Natl Yang Ming Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu 300093, Taiwan

来源：

BIOCONJUGATE CHEMISTRY | 2023年 / 34卷 / 03期

关键词：

AMPHIPHILIC PEPTIDES; HYDROGEL; NANOFIBERS; DESIGN;

D O I：

10.1021/acs.bioconjchem.3c00032

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report a new peptide-based urchin-shaped structure prepared through two-step self-assembly of tetraphenylethylenediserine (TPE-SS). Hydrogelation generated nanobelts through the first stage of self-assembly of TPE-SS; these nanobelts further transformed on silicon wafers into urchin-like microstructures featuring nanosized spines. The presence of the TPE moiety in the hydrogelator resulted in aggregation-induced emission characteristics both in the solution and in the gel phases. TPE-SS has the lowest molecular weight of any TPE-capped hydrogelator with beta-sheet-like structures under physiological pH. This new design strategy appears to be useful for generating three-dimensional self-assembled microstructures and multifunctional biomaterials. We found that TPE-SS is biocompatible with human mesenchymal stem cells and breast cancer cells, making them potential applications in tissue engineering and biomedical research.

引用

页码：562 / 571

页数：10

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