Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization

被引：25

作者：

Crivelli, Lucia ^{[1
]}

Luis Calandri, Ismael ^{[1
,2
]}

Suemoto, Claudia Kimie

Maria Salinas, Rosa ^{[3
]}

Marcela Velilla, Lina ^{[4
]}

Yassuda, Monica Sanches ^{[5
,6
]}

Caramelli, Paulo ^{[7
]}

Lopera, Francisco ^{[4
]}

Nitrini, Ricardo ^{[5
]}

Emilio Sevlever, Gustavo ^{[1
]}

Luisa Sosa, Ana ^{[3
]}

Acosta, Daisy ^{[8
]}

Charamelo Baietti, Ana Maria ^{[9
,10
]}

Isabel Cusicanqui, Maria ^{[11
]}

Custodio, Nilton ^{[12
,13
]}

Dansilio De Simone, Sergio ^{[10
]}

Delgado Derio, Carolina ^{[14
,15
]}

Duque-Penailillo, Lissette ^{[16
]}

Carlos Duran, Juan ^{[11
]}

Jimenez-Velazquez, Ivonne Z. ^{[17
]}

Leon-Salas, Jorge Mario ^{[18
]}

Bergamo, Yanina ^{[19
]}

Florencia Clarens, Maria ^{[1
]}

Damian, Andres ^{[20
]}

Demey, Ignacio ^{[1
]}

Belen Helou, Maria ^{[1
]}

Marquez, Carlos ^{[21
]}

Eugenia Martin, Maria

Morais Martin, Maria da Graca ^{[22
]}

Querze, Diego ^{[23
]}

Ignacio Surace, Ezequiel ^{[24
]}

Acosta-Egea, Sabrina

Aguirre-Salvador, Esteban ^{[16
]}

de Souza, Leonardo Cruz ^{[7
]}

da Cunha Peixoto Cancado, Gustavo Henrique ^{[25
]}

Dozzi Brucki, Sonia Maria ^{[5
]}

Friedlaender, Clarisse Vasconcelos ^{[7
]}

Gomes, Karina Braga ^{[26
]}

Gutierrez, Myriam ^{[27
]}

Laforcada Rios, Carlos ^{[11
]}

Martinez Galindo, Joyce Graciela ^{[3
]}

Montesinos, Rosa

Nunez-Herrera, Alberto ^{[16
]}

Ospina-Henao, Sebastian ^{[28
]}

Rodriguez, Guillermina ^{[29
]}

Ruiz Masson, Victoria ^{[16
]}

Sanchez, Monica ^{[16
]}

Schenk, Christian E. ^{[30
,31
]}

Soto, Ligia ^{[16
]}

Barbosa, Maira Tonidandel ^{[7
]}

机构：

[1] Fleni, Dept Cognit Neurol, Buenos Aires, DF, Argentina

[2] Univ Sao Paulo, Div Geriat, Med Sch, Sao Paulo, Brazil

[3] Lab Demencias Inst Nacl Neurol & Neurocirug Manue, Mexico City, DF, Mexico

[4] Univ Antioquia, Neurosci Grp, Antioquia Med Sch, Medellin, Colombia

[5] Univ Sao Paulo, Sch Med, Cognit & Behav Neurol Unit, Dept Neurol, Sao Paulo, SP, Brazil

[6] Univ Sao Paulo, Sch Arts Sci & Humanities, Gerontol, Sao Paulo, Brazil

[7] Univ Fed Minas Gerais, Behav & Cognit Neurol Unit, Fac Med, Belo Horizonte, MG, Brazil

[8] Univ Nacl Pedro Henriquez Urena UNPHU, Dept Internal Med, Santo Domingo, Dominican Rep

[9] Clin Mem Hosp Britan, Montevideo, Uruguay

[10] Univ Republica, Fac Med Hosp Clin, Dept Neuropsicol, Montevideo, Uruguay

[11] Ctr Neurol Mente Act, La Paz, Bolivia

[12] Inst Peruano Neurociencias, Unidad Diag Deterioro Cognit & Prevenc Demencia, Lima, Peru

[13] Univ Privada San Juan Bautista, Escuela Profes Med Humana, Lima, Peru

[14] Hosp Clin Univ Chile, Dept Neurol & Neurocirug, Unidad Cerebro Saludable, Santiago, Chile

[15] Neuromedicenter, Cognit Disorders Unit, Quito, Ecuador

[16] Univ Puerto Rico, Dept Med Interna Recinto Ciencias Med, Ctr Invest Geriat, San Juan, PR USA

[17] Hosp Clin Bibl, Life Sci Res Inst, Dept Invest Clin, San Jose, Costa Rica

[18] Fleni, Dept Diagnost Imaging, Buenos Aires, DF, Argentina

[19] CUDIM Ctr Uruguayo Imagenol Mol, Montevideo, Uruguay

[20] Univ Chile, Inst Nutr Tecnol Ios Alimentos, Santiago, Chile

[21] Univ Sao Paulo, Dept Radiol HCFMUSP, Sch Med, Sao Paulo, Brazil

[22] Fleni, Dept Neurol, Buenos Aires, DF, Argentina

[23] Fleni, Dept Mol Biol & Bioinformat, Buenos Aires, DF, Argentina

[24] Univ Fed Minas Gerais, Escola Educ Fis Fisioterapia & Terapia Ocupac, Belo Horizonte, MG, Brazil

[25] Univ Fed Minas Gerais, Fac Farm, Belo Horizonte, MG, Brazil

[26] Univ Chile, Dept Neurociencia, Fac Med, Unidad Cerebro Saludable, Santiago, Chile

[27] Univ Ciencias Med, Inst Invest Ciencias Med, Fac Med, San Jose, Costa Rica

[28] Minist Publ Hlth, Dept Demog & Biostat, Santo Domingo, Dominican Rep

[29] Univ Puerto Rico, Div Neurol, Med Sci Campus, San Juan, PR USA

[30] Univ Cent Ecuador, Inbiomed Inst Invest Biomed, Quito, Ecuador

[31] Wake Forest Univ, Dept Internal Med, Sch Med, Winston Salem, NC USA

[32] Wake Forest Univ, Dept Biostat & Data Sci, Sch Med, Winston Salem, NC USA

[33] Karolinska Inst, Div Clin Geriat, Stockholm, Sweden

[34] Karolinska Inst, Ctr Alzheimer Res, Div Clin Geriat, Stockholm, Sweden

[35] Karolinska Univ Hosp, Theme Inflammat & Aging, Stockholm, Sweden

[36] Univ Eastern Finland, Inst Publ Hlth & Clin Nut, Kuopio, Finland

[37] Imperial Coll London, Sch Publ Hlth, Ageing Epidemiol Res Unit, London, England

[38] Wake Forest Univ, Bowman Gray Sch Med, Dept Internal Med, Winston Salem, NC USA

[39] Wake Forest Univ, Bowman Gray Sch Med, Dept Neurol, Winston Salem, NC USA

[40] Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC USA

[41] Alzheimers Assoc, Chicago, IL USA

[42] Univ Costa CUC, Dept Neurosci, Barranquilla, Colombia

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 09期

关键词：

Alzheimer's disease; cognitive impairment; dementia lifestyle; multidomain intervention; prevention; randomized controlled trial; World-Wide FINGERS; DEMENTIA;

D O I：

10.1002/alz.13101

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

INTRODUCTION: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization. METHODS: This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries. RESULTS: Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome). DISCUSSION: LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design.

引用

页码：4046 / 4060

页数：15

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