Incidence and influencing factors of post-stroke cognitive impairment in convalescent young patients with first-ever stroke

Objective: To investigate the occurrence of post-stroke cognitive impairment (PSCI) and its influencing factors in convalescent young patients with first-ever stroke.Methods: A total of 300 first-ever young stroke patients (age <= 45 years) were collected. The Mini-Mental State Examination (MMSE) was used to assess the cognitive status. The sociodemographic data, clinical symptoms, social environment, and behavior-related information were collected and analyzed.Results: The incidence of PSCI in young stroke patients was 62.33 %. Through univariate analysis, there were statistical differences in different levels of education, smoking status and hypertension (P < 0.05). With subsequently multivariate logistic regression analysis, it was found that junior high school (OR=8.58,95 % CI:2.25 similar to 32.70) and high school (OR=10.50,95 %CI:2.69 similar to 41.00) education levels, lesion volume >3.00 cm(3) (OR=8.03,95 %CI:2.28 similar to 28.36), stroke in the frontal-parietal-temporal region (OR=7.26,95 %CI:1.58 similar to 33.40) and the basal ganglia area (OR=6.13,95 %CI:1.24 similar to 30.43), high NIHSS score (OR=1.17,95 %CI: 1.06 similar to 1.29), and high diastolic blood pressure variability coefficient (OR=1.43,95 %CI: 1.02 similar to 2.01) were risk factors for PSCI. Meanwhile, 24 <= BMI < 28 (OR=0.06,95 %CI:0.02 similar to 0.23) and BMI<24 (OR=0.18,95 %CI:0.06 similar to 0.53), hospitalization cost >20,000/month (OR=0.22,95 %CI:0.09 similar to 0.56), and stroke onset in spring and summer (OR=0.37,95 %CI:0.14 similar to 0.96) were protective factors.Conclusion: The incidence of PSCI is relatively high in young stroke patients. Junior high and high school education, stroke lesions >3.00cm(3), strokes in the frontal-parietal-temporal and basal ganglia regions, high NIHSS scores, and high DBPV are risk factors for PSCI in young stroke patients. Meanwhile, BMI<28, treatment cost >20,000/month, and stroke onset in spring and summer are protective factors for PSCI in young stroke patients.