A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

被引：6
作者：
Breslin, Thomas [1 ]
Paino, Jason [2 ]
Wegner, Marie [3 ]
Engels, Elette [2 ,4 ]
Fiedler, Stefan [5 ]
Forrester, Helen [6 ]
Rennau, Hannes [7 ]
Bustillo, John [2 ]
Cameron, Matthew [4 ]
Hausermann, Daniel [4 ]
Hall, Christopher [4 ]
Krause, Dieter [3 ]
Hildebrandt, Guido [7 ]
Lerch, Michael [2 ]
Schueltke, Elisabeth [7 ]
机构：
[1] Lund Univ, Dept Oncol, Clin Sci, S-22185 Lund, Sweden
[2] Univ Wollongong, Ctr Med Radiat Phys, Wollongong 2522, Australia
[3] Hamburg Univ Technol, Inst Prod Dev & Mech Engn Design, D-21073 Hamburg, Germany
[4] Australian Synchrotron ANSTO, Clayton 3168, Australia
[5] European Mol Biol Lab EMBL, Hamburg Outstat, D-22607 Hamburg, Germany
[6] Royal Melbourne Inst Technol RMIT Univ, Sch Sci, Melbourne 3001, Australia
[7] Rostock Univ Med Ctr, Dept Radiooncol, D-18059 Rostock, Germany
来源：
BIOMIMETICS | 2023年 / 8卷 / 02期
关键词：
anthropomorphic phantom; CT scan; dosimetry; experimental radiotherapy; microbeam radiotherapy (MRT); tissue-equivalent materials; therapy planning;
D O I：
10.3390/biomimetics8020230
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.
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页数：11
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