A Novel Anthropomorphic Phantom Composed of Tissue-Equivalent Materials for Use in Experimental Radiotherapy: Design, Dosimetry and Biological Pilot Study

被引：9

作者：

Breslin, Thomas ^{[1
]}

Paino, Jason ^{[2
]}

Wegner, Marie ^{[3
]}

Engels, Elette ^{[2
,4
]}

Fiedler, Stefan ^{[5
]}

Forrester, Helen ^{[6
]}

Rennau, Hannes ^{[7
]}

Bustillo, John ^{[2
]}

Cameron, Matthew ^{[4
]}

Hausermann, Daniel ^{[4
]}

Hall, Christopher ^{[4
]}

Krause, Dieter ^{[3
]}

Hildebrandt, Guido ^{[7
]}

Lerch, Michael ^{[2
]}

Schueltke, Elisabeth ^{[7
]}

机构：

[1] Lund Univ, Dept Oncol, Clin Sci, S-22185 Lund, Sweden

[2] Univ Wollongong, Ctr Med Radiat Phys, Wollongong 2522, Australia

[3] Hamburg Univ Technol, Inst Prod Dev & Mech Engn Design, D-21073 Hamburg, Germany

[4] Australian Synchrotron ANSTO, Clayton 3168, Australia

[5] European Mol Biol Lab EMBL, Hamburg Outstat, D-22607 Hamburg, Germany

[6] Royal Melbourne Inst Technol RMIT Univ, Sch Sci, Melbourne 3001, Australia

[7] Rostock Univ Med Ctr, Dept Radiooncol, D-18059 Rostock, Germany

来源：

BIOMIMETICS | 2023年 / 8卷 / 02期

关键词：

anthropomorphic phantom; CT scan; dosimetry; experimental radiotherapy; microbeam radiotherapy (MRT); tissue-equivalent materials; therapy planning;

D O I：

10.3390/biomimetics8020230

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The production of anthropomorphic phantoms generated from tissue-equivalent materials is challenging but offers an excellent copy of the typical environment encountered in typical patients. High-quality dosimetry measurements and the correlation of the measured dose with the biological effects elicited by it are a prerequisite in preparation of clinical trials with novel radiotherapy approaches. We designed and produced a partial upper arm phantom from tissue-equivalent materials for use in experimental high-dose-rate radiotherapy. The phantom was compared to original patient data using density values and Hounsfield units obtained from CT scans. Dose simulations were conducted for broad-beam irradiation and microbeam radiotherapy (MRT) and compared to values measured in a synchrotron radiation experiment. Finally, we validated the phantom in a pilot experiment with human primary melanoma cells.

引用

页数：11

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