Curcumin a Natural Phenol and Its Therapeutic Role in Cancer and Photodynamic Therapy: A Review

被引：57

作者：

Kah, Glory ^{[1
]}

Chandran, Rahul ^{[1
]}

Abrahamse, Heidi ^{[1
]}

机构：

[1] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Johannesburg, South Africa

来源：

PHARMACEUTICS | 2023年 / 15卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

curcumin; bioavailability; cancer therapy; photodynamic therapy; natural photosensitize; mechanisms of action; nanotechnology; VISIBLE-LIGHT; BLUE-LIGHT; APOPTOSIS; PHOTOSENSITIZERS; MECHANISMS; CELLS; CHEMOPREVENTION; PREVENTION; INHIBITION; MICRORNA;

D O I：

10.3390/pharmaceutics15020639

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cancer continues to cause an alarming number of deaths globally, and its burden on the health system is significant. Though different conventional therapeutic procedures are exploited for cancer treatment, the prevalence and death rates remain elevated. These, therefore, insinuate that novel and more efficient treatment procedures are needed for cancer. Curcumin, a bioactive, natural, phenolic compound isolated from the rhizome of the herbaceous plant turmeric, is receiving great interest for its exciting and broad pharmacological properties. Curcumin presents anticancer therapeutic capacities and can be utilized as a photosensitizing drug in cancer photodynamic therapy (PDT). Nonetheless, curcumin ' s poor bioavailability and related pharmacokinetics limit its clinical utility in cancer treatment. This review looks at the physical and chemical properties, bioavailability, and safety of curcumin, while focusing on curcumin as an agent in cancer therapy and as a photosensitizer in cancer PDT. The possible mechanisms and cellular targets of curcumin in cancer therapy and PDT are highlighted. Furthermore, recent improvements in curcumin's bioavailability in cancer therapy using nanoformulations and delivery systems are presented.

引用

页数：21

共 143 条

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