Power Doppler signal at the enthesis and bone erosions are the most discriminative OMERACT ultrasound lesions for SpA: results from the DEUS (Defining Enthesitis on Ultrasound in Spondyloarthritis) multicentre study

被引：14

作者：

Di Matteo, Andrea ^{[1
,2
]}

Smerilli, Gianluca ^{[1
]}

Di Donato, Stefano ^{[2
]}

Liu, An Ran ^{[3
]}

Becciolini, Andrea ^{[4
]}

Camarda, Federica ^{[5
]}

Cazenave, Tomas ^{[6
]}

Cipolletta, Edoardo ^{[1
]}

Corradini, Davide ^{[7
]}

de Agustin, Juan Jose ^{[8
]}

Destro Castaniti, Giulia Maria ^{[5
]}

Di Donato, Eleonora ^{[4
]}

Di Geso, Luca ^{[9
]}

Duran, Emine ^{[10
]}

Farisogullari, Bayram ^{[10
]}

Fornaro, Marco ^{[11
]}

Francioso, Francesca ^{[1
]}

Giorgis, Pamela ^{[6
]}

Granel, Amelia ^{[12
]}

Hernandez-Diaz, Cristina ^{[13
]}

Horvath, Rudolf ^{[14
]}

Hurnakova, Jana ^{[14
]}

Jesus, Diogo ^{[15
,16
]}

Karadag, Omer ^{[10
]}

Li, Ling ^{[17
]}

Marin, Josefina ^{[18
]}

Martire, Maria Victoria ^{[12
]}

Michelena, Xabier ^{[8
]}

Moscioni, Erica ^{[1
]}

Muntean, Laura ^{[19
]}

Piga, Matteo ^{[7
]}

Rosemffet, Marcos ^{[6
]}

Rovisco, Joao ^{[20
]}

Sahin, Didem ^{[2
]}

Salaffi, Fausto ^{[1
]}

Saraiva, Liliana ^{[20
]}

Scioscia, Crescenzio ^{[11
]}

Tamas, Maria-Magdalena ^{[19
]}

Tanimura, Shun ^{[21
]}

Venetsanopoulou, Aliki ^{[22
]}

Ventura-Rios, Lucio ^{[23
]}

Villota, Orlando ^{[24
,25
]}

Villota-Eraso, Catalina ^{[25
]}

Voulgari, Paraskevi V. ^{[22
]}

Vukatana, Gentiana ^{[26
]}

Hereter, Johana Zacariaz ^{[18
]}

Marzo-Ortega, Helena ^{[2
]}

Grassi, Walter ^{[1
]}

Filippucci, Emilio ^{[1
]}

机构：

[1] Polytech Univ Marche, Carlo Urbani Hosp, Dept Clin & Mol Sci, Rheumatol Unit, Ancona, Italy

[2] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England

[3] Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China

[4] Univ Parma, Azienda Osped, Parma, Italy

[5] Univ Palermo, Dept Hlth Promot Mother & Child Care, Rheumatol Sect, Palermo, Italy

[6] Inst Rehabil Psicofis, Buenos Aires, Argentina

[7] Univ Cagliari, Rheumatol Unit, Cagliari, Italy

[8] Hosp Univ Vall dHebron, Rheumatol Unit, Barcelona, Spain

[9] Prov Hosp Madonna del Soccorso, Dept Internal Med, San Benedetto Tronto, Italy

[10] Hacettepe Univ, Fac Med, Div Rheumatol, Ankara, Turkiye

[11] Univ Bari, Dept Precis & Regenerat Med, Ionian Area DiMePRe J Rheumatol Unit, Bari, Italy

[12] Hosp San Roque Gonnet, Rheumatol, La Plata, Buenos Aires, Argentina

[13] Hosp Juarez Mexico, Rheumatol Dept, Mexico City, Mexico

[14] Motol Univ Hosp, Dept Paediat & Adult Rheumatol, Prague, Czech Republic

[15] Leiria Hosp Ctr, Rheumatol Dept, Pousos, Portugal

[16] Univ Beira Interior, Fac Hlth Sci, Covilha, Portugal

[17] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Rheumatol & Immunol, Guangzhou, Guangdong, Peoples R China

[18] Hosp Italiano Buenos Aires, Dept Internal Med, Rheumatol Unit, Buenos Aires, Argentina

[19] Iuliu Hatieganu Univ Med & Pharm, Dept Rheumatol, Cluj napoca, Romania

[20] Ctr Hosp & Univ Coimbra EPE, Rheumatol Dept, Coimbra, Portugal

[21] Hokkaido Med Ctr, Dept Rheumatol, Sapporo, Japan

[22] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Rheumatol, Ioannina, Greece

[23] Natl Inst Rehabil Luis Guillermo Ibarra, Div Rheumatol, Ciudad De Mexico, Mexico

[24] Fdn Hosp San Pedro, Div Rheumatol, San Juan De Pasto, Colombia

[25] Dept Rheumatol, Serv Integral Reumatol Inmunol Doctor Orlando Vill, Pasto, Colombia

[26] IRCCS Azienda Osped Univ Bologna, IRCCS Azienda Ospedaliero Universitaria Bologna Po, Policlin St Orsola, Bologna, Italy

来源：

ANNALS OF THE RHEUMATIC DISEASES | 2024年 / 83卷 / 07期

关键词：

Ultrasonography; Spondylitis; Ankylosing; Arthritis; Psoriatic; Osteoarthritis; Fibromyalgia; SOCIETY CLASSIFICATION CRITERIA; PSORIATIC-ARTHRITIS; AXIAL SPONDYLOARTHRITIS; ANKYLOSING-SPONDYLITIS; CLINICAL ENTHESITIS; DISEASE-ACTIVITY; ULTRASONOGRAPHY; OSTEOARTHRITIS; PREVALENCE; ASDAS;

D O I：

10.1136/ard-2023-225443

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives To assess, in spondyloarthritis (SpA), the discriminative value of the Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and their associations with clinical features in this population. Methods In this multicentre study involving 20 rheumatology centres, clinical and ultrasound examinations of the lower limb large entheses were performed in 413 patients with SpA (axial SpA and psoriatic arthritis) and 282 disease controls (osteoarthritis and fibromyalgia). 'Active enthesitis' was defined as (1) power Doppler (PD) at the enthesis grade >= 1 plus entheseal thickening and/or hypoechoic areas, or (2) PD grade >1 (independent of the presence of entheseal thickening and/or hypoechoic areas). Results In the univariate analysis, all OMERACT lesions except enthesophytes/calcifications showed a significant association with SpA. PD (OR=8.77, 95% CI 4.40 to 19.20, p<0.001) and bone erosions (OR=4.75, 95% CI 2.43 to 10.10, p<0.001) retained this association in the multivariate analysis. Among the lower limb entheses, only the Achilles tendon was significantly associated with SpA (OR=1.93, 95% CI 1.30 to 2.88, p<0.001) in the multivariate analyses. Active enthesitis showed a significant association with SpA (OR=9.20, 95% CI 4.21 to 23.20, p<0.001), and unlike the individual OMERACT ultrasound lesions it was consistently associated with most clinical measures of SpA disease activity and severity in the regression analyses. Conclusions This large multicentre study assessed the value of different ultrasound findings of enthesitis in SpA, identifying the most discriminative ultrasound lesions and entheseal sites for SpA. Ultrasound could differentiate between SpA-related enthesitis and other forms of entheseal pathology (ie, mechanical enthesitis), thus improving the assessment of entheseal involvement in SpA.

引用

页码：847 / 857

页数：11

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