Involvement of CXCL12/CXCR4 axis in colorectal cancer: a mini-review

被引：15
作者：
Bocchi, Mayara [1 ]
Pereira, Nathalia de Sousa [1 ]
de Oliveira, Karen Brajao [1 ,2 ]
Amarante, Marla Karine [1 ]
机构：
[1] Univ Estadual Londrina, Hlth Sci Ctr, Dept Pathol Clin & Toxicol Anal, Oncol Lab, Londrina, PR, Brazil
[2] Univ Estadual Londrina, Biol Sci Ctr, Dept Pathol Sci, Londrina, PR, Brazil
来源：
MOLECULAR BIOLOGY REPORTS | 2023年 / 50卷 / 07期
关键词：
Chemokines; Chemokine receptors; Colorectal cancer; CXCL12; CXCR4; TUMOR; EXPRESSION; LY2510924; HALLMARKS; CELLS; HYPERMETHYLATION; COMBINATION; PROGRESSION; INHIBITION; ANTAGONIST;
D O I：
10.1007/s11033-023-08479-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Migration of metastatic tumor cells is similar to the traffic of leukocytes and has been reported that can be guided by chemokines and their receptors, through the circulation to distant organs. The chemokine CXCL12 and its receptor CXCR4 play an essential role in hematopoietic stem cell homing and the activation of this axis supports malignant events. Binding of CXCL12 to CXCR4 activates signal transduction pathways, with broad effects on chemotaxis, cell proliferation, migration and gene expression. Thus, this axis serves as a bridge for tumor-stromal cell communication, creating a permissive microenvironment for tumor development, survival, angiogenesis and metastasis. Evidence suggests that this axis may be involved in the colorectal cancer (CRC) carcinogenesis. Therefore, we review emerging data and correlations between CXCL12/CXCR4 axis in CRC, the implications for cancer progression and possible therapeutic strategies that exploit this system.
引用
收藏
页码：6233 / 6239
页数：7
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