Endocrine functions of the heart: from bench to bedside

被引：26

作者：

Volpe, Massimo ^{[1
,2
]}

Gallo, Giovanna ^{[1
]}

Rubattu, Speranza ^{[1
,3
]}

机构：

[1] Sapienza Univ Rome, Dept Clin & Mol Med, Via Grottarossa 1035, I-00189 Rome, Italy

[2] IRCCS San Raffaele, Via Pisana 235, I-00163 Rome, Italy

[3] IRCCS Neuromed, Via Atinense 18, I-86077 Pozzilli, IS, Italy

来源：

EUROPEAN HEART JOURNAL | 2023年 / 44卷 / 08期

关键词：

Cardiac natriuretic peptides; Secretion; Epigenetics; Cardiovascular diseases; Biomarkers; Therapy; ATRIAL-NATRIURETIC-PEPTIDE; BLOOD-PRESSURE REGULATION; LONG-TERM SURVIVAL; HEMODYNAMIC-RESPONSES; NEPRILYSIN INHIBITION; CONVERTING ENZYME; GENETIC VARIANT; CARDIAC EVENTS; FACTOR RELEASE; DOUBLE-BLIND;

D O I：

10.1093/eurheartj/ehac759

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart has a recognized endocrine function as it produces several biologically active substances with hormonal properties. Among these hormones, the natriuretic peptide (NP) system has been extensively characterized and represents a prominent expression of the endocrine function of the heart. Over the years, knowledge about the mechanisms governing their synthesis, secretion, processing, and receptors interaction of NPs has been intensively investigated. Their main physiological endocrine and paracrine effects on cardiovascular and renal systems are mostly mediated through guanylate cyclase-A coupled receptors. The potential role of NPs in the pathophysiology of heart failure and particularly their counterbalancing action opposing the overactivation of renin-angiotensin-aldosterone and sympathetic nervous systems has been described. In addition, NPs are used today as key biomarkers in cardiovascular diseases with both diagnostic and prognostic significance. On these premises, multiple therapeutic strategies based on the biological properties of NPs have been attempted to develop new cardiovascular therapies. Apart from the introduction of the class of angiotensin receptor/neprilysin inhibitors in the current management of heart failure, novel promising molecules, including M-atrial natriuretic peptide (a novel atrial NP-based compound), have been tested for the treatment of human hypertension. The development of new drugs is currently underway, and we are probably only at the dawn of novel NPs-based therapeutic strategies. The present article also provides an updated overview of the regulation of NPs synthesis and secretion by microRNAs and epigenetics as well as interactions of cardiac hormones with other endocrine systems.

引用

页码：643 / 655

页数：13

共 169 条

[91] Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure [J].

McMurray, John J. V. ;

Packer, Milton ;

Desai, Akshay S. ;

Gong, Jianjian ;

Lefkowitz, Martin P. ;

Rizkala, Adel R. ;

Rouleau, Jean L. ;

Shi, Victor C. ;

Solomon, Scott D. ;

Swedberg, Karl ;

Zile, Michael R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (11) :993-1004

[92]

Messerli Franz H, 2017, JACC Heart Fail, V5, P543, DOI 10.1016/j.jchf.2017.04.012

[93] Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats [J].

Mezo, Adam R. ;

McDonnell, Kevin A. ;

Low, Susan C. ;

Song, Jeff ;

Reidy, Tom J. ;

Lu, Qi ;

Amari, John V. ;

Hoehn, Todd ;

Peters, Robert T. ;

Dumont, Jennifer ;

Bitonti, Alan J. .

BIOCONJUGATE CHEMISTRY, 2012, 23 (03) :518-526

[94] Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity [J].

Miyashita, Kazutoshi ;

Itoh, Hiroshi ;

Tsujimoto, Hirokazu ;

Tamura, Naohisa ;

Fukunaga, Yasutomo ;

Sone, Masakatsu ;

Yamahara, Kenichi ;

Taura, Daisuke ;

Inuzuka, Megumi ;

Sonoyama, Takuhiro ;

Naka, Kazuwa .

DIABETES, 2009, 58 (12) :2880-2892

[95] The 2014 Canadian Cardiovascular Society Heart Failure Management Guidelines Focus Update: Anemia, Biomarkers, and Recent Therapeutic Trial Implications [J].

Moe, Gordon W. ;

Ezekowitz, Justin A. ;

O'Meara, Eileen ;

Lepage, Serge ;

Howlett, Jonathan G. ;

Fremes, Steve ;

Al-Hesayen, Abdul ;

Heckman, George A. ;

Abrams, Howard ;

Ducharme, Anique ;

Estrella-Holder, Estrellita ;

Grzeslo, Adam ;

Harkness, Karen ;

Koshman, Sheri L. ;

McDonald, Michael ;

McKelvie, Robert ;

Rajda, Miroslaw ;

Rao, Vivek ;

Swiggum, Elizabeth ;

Virani, Sean ;

Zieroth, Shelley ;

Arnold, J. Malcolm O. ;

Ashton, Tom ;

D'Astous, Michel ;

Chan, Michael ;

De, Sabe ;

Dorian, Paul ;

Giannetti, Nadia ;

Haddad, Haissam ;

Isaac, Debra L. ;

Kouz, Simon ;

Leblanc, Marie-Helene ;

Liu, Peter ;

Ross, Heather J. ;

Sussex, Bruce ;

White, Michel .

CANADIAN JOURNAL OF CARDIOLOGY, 2015, 31 (01) :3-16

[96] C-type natriuretic peptide co-ordinates cardiac structure and function [J].

Moyes, Amie J. ;

Chu, Sandy M. ;

Aubdool, Aisah A. ;

Dukinfield, Matthew S. ;

Margulies, Kenneth B. ;

Bedi, Kenneth C., Jr. ;

Hodivala-Dilke, Kairbaan ;

Baliga, Reshma S. ;

Hobbs, Adrian J. .

EUROPEAN HEART JOURNAL, 2020, 41 (09) :1006-1020

[97] Endothelial C-type natriuretic peptide maintains vascular homeostasis [J].

Moyes, Amie J. ;

Khambata, Rayomand S. ;

Villar, Inmaculada ;

Bubb, Kristen J. ;

Baliga, Reshma S. ;

Lumsden, Natalie G. ;

Xiao, Fang ;

Gane, Paul J. ;

Rebstock, Anne-Sophie ;

Worthington, Roberta J. ;

Simone, Michela I. ;

Mota, Filipa ;

Rivilla, Fernando ;

Vallejo, Susana ;

Peiro, Concepcion ;

Sanchez Ferrer, Carlos F. ;

Djordjevic, Snezana ;

Caulfield, Mark J. ;

MacAllister, Raymond J. ;

Selwood, David L. ;

Ahluwalia, Amrita ;

Hobbs, Adrian J. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (09) :4039-4051

[98] Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations [J].

Mueller, Christian ;

McDonald, Kenneth ;

de Boer, Rudolf A. ;

Maisel, Alan ;

Cleland, John G. F. ;

Kozhuharov, Nikola ;

Coats, Andrew J. S. ;

Metra, Marco ;

Mebazaa, Alexandre ;

Ruschitzka, Frank ;

Lainscak, Mitja ;

Filippatos, Gerasimos ;

Seferovic, Petar M. ;

Meijers, Wouter C. ;

Bayes-Genis, Antoni ;

Mueller, Thomas ;

Richards, Mark ;

Januzzi, James L., Jr. .

EUROPEAN JOURNAL OF HEART FAILURE, 2019, 21 (06) :715-731

[99]

Murakami Y, 2002, CAN J CARDIOL, V18, P1294

[100] Atrial Natriuretic Peptide and Treatment With Sacubitril/Valsartan in Heart Failure With Reduced Election Fraction [J].

Murphy, Sean P. ;

Prescott, Margaret F. ;

Camacho, Alexander ;

Iyer, Seethalakshmi R. ;

Maisel, Alan S. ;

Felker, G. Michael ;

Butler, Javed ;

Pina, Ileana L. ;

Ibrahim, Nasrien E. ;

Abbas, Cheryl ;

Burnett, John C., Jr. ;

Solomon, Scott D. ;

Januzzi, James L. .

JACC-HEART FAILURE, 2021, 9 (02) :127-136

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