Synthesis of the Core/Shell Structure of Polycaprolactone@Curcumin-Gluten for Drug Delivery Applications

被引：2
作者：
Rami, Mina Rezghi [1 ]
Forouzandehdel, Shayan [2 ]
Salami, Masoumeh [3 ]
Hataminejad, Elaheh [3 ]
Jafar, Mohammadreza [3 ]
机构：
[1] KNT Univ Technol, Chem Dept, Tehran, Iran
[2] Sharif Univ Technol, Dept Chem, POB 11155-9516, Tehran, Iran
[3] Islamic Azad Univ, Fac Sci, Dept Chem, Cent Tehran Branch, Tehran, Iran
来源：
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2023年 / 13卷 / 01期
关键词：
polycaprolactone; curcumin; gluten; drug delivery; IN-VITRO; CHITOSAN; MICELLES; MICROCAPSULES; NANOFIBERS; COPOLYMERS;
D O I：
10.33263/BRIAC131.087
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this study, polycaprolactone (PCL) nanoparticles were effectively synthesized as novel drug delivery systems by the electrospray method. Curcumin (Cur) was selected as the model drug with further enhanced stability of its composition with gluten (GLU). The physical-chemical characterization, including FTIR, UV-vis, and thermal analysis of PCL@Cur-GLU nanocapsules, are explored. The in vitro release profiles described by Ritger-Peppas models were also investigated, showing sustained release for 15 h after a burst release within the first five hours.
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页数：11
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