Serotonin neurons in mating female mice are activated by male ejaculation

被引：3

作者：

Troconis, Eileen L. ^{[1
]}

Seo, Changwoo ^{[2
,3
]}

Guru, Akash ^{[2
,3
]}

Warden, Melissa R. ^{[2
,3
]}

机构：

[1] Cornell Univ, Biol & Biomed Sci Program, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Neurobiol & Behav, Ithaca, NY 14853 USA

[3] Cornell Univ, Cornell Neurotech, Ithaca, NY 14853 USA

来源：

CURRENT BIOLOGY | 2023年 / 33卷 / 22期

关键词：

DORSAL RAPHE NUCLEUS; AFFERENT-FIBERS; VAGINOCERVICAL STIMULATION; SEXUAL-BEHAVIOR; NEURAL CIRCUITS; ESTROUS-CYCLE; REPRODUCTIVE-BEHAVIOR; SPERM TRANSPORT; LUTEAL ACTIVITY; VAGINAL CERVIX;

D O I：

10.1016/j.cub.2023.09.071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sexual stimulation triggers changes in female physiology and behavior, including sexual satiety and prepar-ing the uterus for pregnancy. Serotonin (5-HT) is an important regulator of reproductive physiology and sex-ual receptivity, but the relationship between sexual stimulation and 5-HT neural activity in females is poorly understood. Here, we investigated dorsal raphe 5-HT neural activity in female mice during sexual behavior. We found that 5-HT neural activity in mating females peaked specifically upon male ejaculation and remained elevated above baseline until disengagement. Artificial intravaginal mechanical stimulation was sufficient to elicit increased 5-HT neural activity but the delivery of ejaculatory fluids was not. Distal penis expansion ("penile cupping") at ejaculation and forceful expulsion of ejaculatory fluid each provided sufficient mechan-ical stimulation to elicit 5-HT neuron activation. Our study identifies a female ejaculation-specific signal in a major neuromodulatory system and shows that intravaginal mechanosensory stimulation is necessary and sufficient to drive this signal.

引用

页码：4926 / +

页数：16

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