An overview: metal-based inhibitors of urease

被引:20
|
作者
Yang, Wei [1 ,2 ]
Peng, Zhiyun [1 ]
Wang, Guangcheng [2 ]
机构
[1] Guizhou Med Univ, Clin Trails Ctr, Affiliated Hosp, Guiyang, Peoples R China
[2] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guizhou Prov Key Lab Pharmaceut, Guiyang, Peoples R China
关键词
Urease; metal-based urease inhibitor; structure-activity relationship; molecular docking; SCHIFF-BASE; CRYSTAL-STRUCTURES; COPPER(II) COMPLEXES; ZINC(II) COMPLEXES; MOLECULAR DOCKING; BIOLOGICAL EVALUATION; IN-VITRO; NITRIFICATION INHIBITORS; GASEOUS EMISSIONS; NI(II) COMPLEXES;
D O I
10.1080/14756366.2022.2150182
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Urease is a kind of nickel-dependent metalloenzyme, which exists in the biological world widely, and can catalyse the hydrolysis of urea into ammonia and carbon dioxide to provide a nitrogen source for organisms. Urease has important uses in agriculture and medicine because it can catalyse the production of ammonia. Therefore, in this review, metal-based inhibitors of urease will be summarised according to different transition metal ions. Including the urease inhibition, structure-activity relationship, and molecular docking. Importantly, among these reviewed effective urease inhibitors, most of copper metal complexes exhibited stronger urease inhibition with IC50 values ranging from 0.46 mu M to 41.1 mu M. Significantly, the collected comprehensive information looks forward to providing rational guidance and effective strategies for the development of novel, potent, and safe metal-based urease inhibitors, which are better for practical applications in the future.
引用
收藏
页码:361 / 375
页数:15
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