An intriguing approach toward antibacterial activity of green synthesized Rutin-templated mesoporous silica nanoparticles decorated with nanosilver

被引：66

作者：

Abbasi, Milad ^{[1
]}

Gholizadeh, Razieh ^{[2
]}

Kasaee, Seyed Reza ^{[3
]}

Vaez, Ahmad ^{[4
]}

Chelliapan, Shreeshivadasan ^{[5
]}

Fadhil Al-Qaim, Fouad ^{[6
]}

Deyab, Issa Farhan ^{[7
]}

Shafiee, Mostafa ^{[1
]}

Zareshahrabadi, Zahra ^{[8
]}

Amani, Ali Mohammad ^{[1
]}

Mosleh-Shirazi, Sareh ^{[2
]}

Kamyab, Hesam ^{[9
,10
]}

机构：

[1] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Nanotechnol, Shiraz, Iran

[2] Shiraz Univ Technol, Dept Mat Sci & Engn, Shiraz, Iran

[3] Shiraz Univ Med Sci, Shiraz Endocrinol & Metab Res Ctr, Shiraz, Iran

[4] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Tissue Engn & Appl Cell Sci, Shiraz, Iran

[5] Univ Teknol Malaysia, Razak Fac Technol & Informat, Dept Engn, Jln Sultan Yahya Petra, Kuala Lumpur 54100, Malaysia

[6] Univ Babylon, Coll Sci Women, Hilla, Iraq

[7] Al Mustaqbal Univ Coll, Dept Med Phys, Hillah 51001, Babil, Iraq

[8] Shiraz Univ Med Sci, Basic Sci Infect Dis Res Ctr, Shiraz, Iran

[9] Saveetha Inst Med & Tech Sci, Dept Biomat, Saveetha Dent Coll & Hosp, Chennai 600077, Tamil Nadu, India

[10] Univ Teknol Malaysia, MJIIT, Jalan Sultan Yahya Petra, Kuala Lumpur 54100, Malaysia

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

关键词：

SILVER NANOPARTICLES; FLAVONOIDS; PARTICLES; EFFICACY; RELEASE;

D O I：

10.1038/s41598-023-33095-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In recent years, mesoporous silica nanoparticles (MSNs) have been applied in various biomedicine fields like bioimaging, drug delivery, and antibacterial alternatives. MSNs could be manufactured through green synthetic methods as environmentally friendly and sustainable synthesis approaches, to improve physiochemical characteristics for biomedical applications. In the present research, we used Rutin (Ru) extract, a biocompatible flavonoid, as the reducing agent and nonsurfactant template for the green synthesis of Ag-decorated MSNs. Transmission electron microscopy (TEM), zeta-potential, x-ray powder diffraction (XRD), fourier transform infrared (FTIR) spectroscopy analysis, scanning electron microscopy (SEM), brunauer-emmett-teller (BET) analysis, and energy-dispersive system (EDS) spectroscopy were used to evaluate the Ag-decorated MSNs physical characteristics. The antimicrobial properties were evaluated against Staphylococcus aureus (S. aureus), Escherichia coli (E. coli), and also different types of candida. The cytotoxicity test was performed by using the MTT assay. Based on the findings, the significant antimicrobial efficacy of Ru-Ag-decorated MSNs against both gram positive and gram negative bacteria and different types of fungi was detected as well as acceptable safety and low cytotoxicity even at lower concentrations. Our results have given a straightforward and cost-effective method for fabricating biodegradable Ag-decorated MSNs. The applications of these MSNs in the domains of biomedicine appear to be promising.

引用

页数：12

共 69 条

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