Roles of macrophages in tumor development: a spatiotemporal perspective

被引：104
作者：
Bied, Mathilde [1 ]
Ho, William W. [2 ]
Ginhoux, Florent [1 ,2 ,3 ,4 ]
Bleriot, Camille [1 ,5 ]
机构：
[1] Inst Gustave Roussy, INSERM U1015, Villejuif, France
[2] ASTAR, Singapore Immunol Network SIgN, Singapore, Singapore
[3] Shanghai Jiao Tong Univ, Shanghai Inst Immunol, Sch Med, Shanghai, Peoples R China
[4] SingHlth Duke NUS, Translat Immunol Inst, Singapore, Singapore
[5] Univ Paris Cite, Inst Necker Enfants Malad, INSERM, CNRS, Paris, France
来源：
CELLULAR & MOLECULAR IMMUNOLOGY | 2023年 / 20卷 / 09期
关键词：
Macrophages; Tumor associated macrophages; Tumor microenvironment; Metastasis; PRE-METASTATIC NICHE; EPITHELIAL-MESENCHYMAL TRANSITIONS; FIBROBLAST ACTIVATION PROTEIN; TRANSCRIPTION FACTOR SNAIL; REGULATORY T-CELLS; SINGLE-CELL; KUPFFER CELLS; E-CADHERIN; IMMUNOSUPPRESSIVE MACROPHAGES; INFLAMMATORY MONOCYTES;
D O I：
10.1038/s41423-023-01061-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Macrophages are critical regulators of tissue homeostasis but are also abundant in the tumor microenvironment (TME). In both primary tumors and metastases, such tumor-associated macrophages (TAMs) seem to support tumor development. While we know that TAMs are the dominant immune cells in the TME, their vast heterogeneity and associated functions are only just being unraveled. In this review, we outline the various known TAM populations found thus far and delineate their specialized roles associated with the main stages of cancer progression. We discuss how macrophages may prime the premetastatic niche to enable the growth of a metastasis and then how subsequent metastasis-associated macrophages can support secondary tumor growth. Finally, we speculate on the challenges that remain to be overcome in TAM research.
引用
收藏
页码：983 / 992
页数：10
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